抗人 UBE2M 抗体对
01AB01398
Ubiquitin conjugating enzyme E2 M (UBE2M), also known as Ubc12, is a crucial mediator in the NEDD8 conjugation pathway. It accepts NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins, particularly cullins. UBE2M is highly conserved across species and plays essential roles in protein neddylation, which regulates various cellular processes including cell cycle progression, signal transduction, and protein degradation. The enzyme is stress-inducible and can function as both a neddylation E2 under physiological conditions and a ubiquitylation E2 under stressed conditions. UBE2M has been implicated in cancer progression, particularly in hepatocellular carcinoma where it promotes cell proliferation via the beta-catenin/cyclin D1 signaling pathway. Additionally, UBE2M is associated with peroxisome biogenesis disorder 6B and has been identified as a potential therapeutic target in cancer treatment.
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技术参数
- 靶点基因名
- UBE2M
- 基因别名
- UBC12
- 蛋白别名
- ubiquitin conjugating enzyme E2 M; UBE2M
- UniProt
- P61081
- 物种
- Human
产品详情
- 靶点名称
- UBE2M
- 蛋白名称
- ubiquitin conjugating enzyme E2 M
- 蛋白别名
- NEDD8-conjugating enzyme Ubc12; NEDD8 carrier protein; Ubiquitin-conjugating enzyme E2 M
- 靶点基因名
- UBE2M
- 基因别名
- UBC12
- UniProt
- P61081
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ubiquitin conjugating enzyme E2 M (UBE2M), also known as Ubc12, is a crucial mediator in the NEDD8 conjugation pathway. It accepts NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins, particularly cullins. UBE2M is highly conserved across species and plays essential roles in protein neddylation, which regulates various cellular processes including cell cycle progression, signal transduction, and protein degradation. The enzyme is stress-inducible and can function as both a neddylation E2 under physiological conditions and a ubiquitylation E2 under stressed conditions. UBE2M has been implicated in cancer progression, particularly in hepatocellular carcinoma where it promotes cell proliferation via the beta-catenin/cyclin D1 signaling pathway. Additionally, UBE2M is associated with peroxisome biogenesis disorder 6B and has been identified as a potential therapeutic target in cancer treatment.