人 UBE2G1 抗体对
01AB02910
Ubiquitin conjugating enzyme E2 G1 (UBE2G1), also known as UBC7, is a core component of the ubiquitin-proteasome system that functions as an E2 ubiquitin-conjugating enzyme. It features a classic β-grasp fold and a conserved active-site cysteine that accepts ubiquitin from E1 activating enzymes via a thioester bond. UBE2G1 catalyzes the covalent attachment of ubiquitin to target substrates, facilitating the formation of Lys-48- and Lys-63-linked polyubiquitin chains. These modifications are critical for the proteasomal degradation of short-lived or misfolded proteins, particularly within the endoplasmic reticulum-associated degradation (ERAD) pathway. The enzyme interacts with various E3 RING ligases through its flexible loop regions to ensure substrate specificity. It is essential for maintaining protein homeostasis and has been implicated in the turnover of muscle-specific proteins.
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技术参数
- 靶点基因名
- UBE2G1
- 基因别名
- UBE2G
- 蛋白别名
- ubiquitin conjugating enzyme E2 G1; UBE2G1
- UniProt
- P62253
- 物种
- Human
产品详情
- 靶点名称
- UBE2G1
- 蛋白名称
- ubiquitin conjugating enzyme E2 G1
- 蛋白别名
- Ubiquitin-conjugating enzyme E2 G1; E2 ubiquitin-conjugating enzyme G1; E217K; UBC7; Ubiquitin carrier protein G1; Ubiquitin-protein ligase G1) [Cleaved into: Ubiquitin-conjugating enzyme E2 G1; N-terminally processed]
- 靶点基因名
- UBE2G1
- 基因别名
- UBE2G
- UniProt
- P62253
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ubiquitin conjugating enzyme E2 G1 (UBE2G1), also known as UBC7, is a core component of the ubiquitin-proteasome system that functions as an E2 ubiquitin-conjugating enzyme. It features a classic β-grasp fold and a conserved active-site cysteine that accepts ubiquitin from E1 activating enzymes via a thioester bond. UBE2G1 catalyzes the covalent attachment of ubiquitin to target substrates, facilitating the formation of Lys-48- and Lys-63-linked polyubiquitin chains. These modifications are critical for the proteasomal degradation of short-lived or misfolded proteins, particularly within the endoplasmic reticulum-associated degradation (ERAD) pathway. The enzyme interacts with various E3 RING ligases through its flexible loop regions to ensure substrate specificity. It is essential for maintaining protein homeostasis and has been implicated in the turnover of muscle-specific proteins.