人 UBE2F 抗体对
01AB03439
Ubiquitin conjugating enzyme E2 F (putative) (UBE2F) is a specialized NEDD8-conjugating enzyme that plays a critical role in the protein neddylation pathway. It accepts NEDD8 from the E1 complex and catalyzes its covalent attachment to specific targets, most notably cullin-5 in complex with the E3 ligase RNF7/RBX2. This neddylation activity is essential for the assembly and activation of Cullin-RING ligase complexes, which regulate the ubiquitylation and proteasomal degradation of various substrates. UBE2F specifically promotes the degradation of the pro-apoptotic protein NOXA, thereby conferring oncogenic growth advantages and resistance to radiation and chemotherapy in cancer cells. Clinically, UBE2F is associated with Three M Syndrome 1, a rare genetic growth disorder. Additionally, its role in facilitating HIV-1 Vif-mediated degradation of APOBEC3G and its upregulation in lung cancer highlight its significance in viral pathogenesis and oncology, positioning it as a potential target for therapeutic intervention.
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技术参数
- 靶点基因名
- UBE2F
- 基因别名
- NCE2
- 蛋白别名
- ubiquitin conjugating enzyme E2 F (putative); UBE2F
- UniProt
- Q969M7
- 物种
- Human
产品详情
- 靶点名称
- UBE2F
- 蛋白名称
- ubiquitin conjugating enzyme E2 F (putative)
- 蛋白别名
- NEDD8-conjugating enzyme UBE2F; NEDD8 carrier protein UBE2F; NEDD8 protein ligase UBE2F; NEDD8-conjugating enzyme 2; RING-type E3 NEDD8 transferase UBE2F; Ubiquitin-conjugating enzyme E2 F
- 靶点基因名
- UBE2F
- 基因别名
- NCE2
- UniProt
- Q969M7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ubiquitin conjugating enzyme E2 F (putative) (UBE2F) is a specialized NEDD8-conjugating enzyme that plays a critical role in the protein neddylation pathway. It accepts NEDD8 from the E1 complex and catalyzes its covalent attachment to specific targets, most notably cullin-5 in complex with the E3 ligase RNF7/RBX2. This neddylation activity is essential for the assembly and activation of Cullin-RING ligase complexes, which regulate the ubiquitylation and proteasomal degradation of various substrates. UBE2F specifically promotes the degradation of the pro-apoptotic protein NOXA, thereby conferring oncogenic growth advantages and resistance to radiation and chemotherapy in cancer cells. Clinically, UBE2F is associated with Three M Syndrome 1, a rare genetic growth disorder. Additionally, its role in facilitating HIV-1 Vif-mediated degradation of APOBEC3G and its upregulation in lung cancer highlight its significance in viral pathogenesis and oncology, positioning it as a potential target for therapeutic intervention.