人 UBASH3A 抗体对
01AB03034
Ubiquitin associated and SH3 domain containing A (UBASH3A) is a cytoplasmic and nuclear adaptor protein predominantly expressed in T cells. It features a ubiquitin-associated (UBA) domain, an SH3 domain, and a phosphatase domain. UBASH3A functions as a negative regulator of T-cell receptor (TCR) signaling and endocytosis by binding ubiquitin, dynamin, and CBL. This interaction inhibits CBL-mediated downregulation of receptor tyrosine kinases, leading to the surface accumulation of activated receptors such as TCR and EGFR. By modulating T-cell activation thresholds, UBASH3A plays a significant role in immune homeostasis. Genetic variants affecting its expression or function are associated with susceptibility to autoimmune conditions, including type 1 diabetes and other immune-mediated disorders.
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技术参数
- 靶点基因名
- UBASH3A
- 基因别名
- STS2
- 蛋白别名
- ubiquitin associated and SH3 domain containing A; UBASH3A
- UniProt
- P57075
- 物种
- Human
产品详情
- 靶点名称
- UBASH3A
- 蛋白名称
- ubiquitin associated and SH3 domain containing A
- 蛋白别名
- Ubiquitin-associated and SH3 domain-containing protein A; Cbl-interacting protein 4; CLIP4; Suppressor of T-cell receptor signaling 2; STS-2; T-cell ubiquitin ligand 1; TULA-1
- 靶点基因名
- UBASH3A
- 基因别名
- STS2
- UniProt
- P57075
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Ubiquitin associated and SH3 domain containing A (UBASH3A) is a cytoplasmic and nuclear adaptor protein predominantly expressed in T cells. It features a ubiquitin-associated (UBA) domain, an SH3 domain, and a phosphatase domain. UBASH3A functions as a negative regulator of T-cell receptor (TCR) signaling and endocytosis by binding ubiquitin, dynamin, and CBL. This interaction inhibits CBL-mediated downregulation of receptor tyrosine kinases, leading to the surface accumulation of activated receptors such as TCR and EGFR. By modulating T-cell activation thresholds, UBASH3A plays a significant role in immune homeostasis. Genetic variants affecting its expression or function are associated with susceptibility to autoimmune conditions, including type 1 diabetes and other immune-mediated disorders.