抗人 TYMP 抗体对
01AB00624
Thymidine phosphorylase (TYMP), also known as platelet-derived endothelial cell growth factor, is a crucial enzyme involved in pyrimidine metabolism, specifically catalyzing the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate. The enzyme's properties include its dimeric structure and specific binding sites that facilitate its catalytic function. This protein, which functions as a homodimer, plays a vital role in maintaining nucleoside homeostasis necessary for DNA repair and replication, with its activity being essential for mitochondrial DNA integrity. Dysregulation or mutations in the TYMP gene are linked to several diseases, notably mitochondrial neurogastrointestinal encephalopathy (MNGIE) syndrome, characterized by mitochondrial dysfunction and severe neurological symptoms due to impaired thymidine salvage pathways. Additionally, TYMP is implicated in cancer biology; its expression is often elevated in various tumors, promoting angiogenesis and tumor growth.
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技术参数
- 靶点基因名
- TYMP
- 基因别名
- ECGF1
- 蛋白别名
- thymidine phosphorylase; TYMP
- UniProt
- P19971
- 物种
- Human
产品详情
- 靶点名称
- TYMP
- 蛋白名称
- thymidine phosphorylase
- 蛋白别名
- Thymidine phosphorylase; TP; Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase
- 靶点基因名
- TYMP
- 基因别名
- ECGF1
- UniProt
- P19971
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Thymidine phosphorylase (TYMP), also known as platelet-derived endothelial cell growth factor, is a crucial enzyme involved in pyrimidine metabolism, specifically catalyzing the reversible phosphorolysis of thymidine to thymine and 2-deoxyribose-1-phosphate. The enzyme's properties include its dimeric structure and specific binding sites that facilitate its catalytic function. This protein, which functions as a homodimer, plays a vital role in maintaining nucleoside homeostasis necessary for DNA repair and replication, with its activity being essential for mitochondrial DNA integrity. Dysregulation or mutations in the TYMP gene are linked to several diseases, notably mitochondrial neurogastrointestinal encephalopathy (MNGIE) syndrome, characterized by mitochondrial dysfunction and severe neurological symptoms due to impaired thymidine salvage pathways. Additionally, TYMP is implicated in cancer biology; its expression is often elevated in various tumors, promoting angiogenesis and tumor growth.