人 TXNDC17 抗体对
01AB03267
Thioredoxin domain containing 17 (TXNDC17) is a small, ubiquitously expressed cytosolic oxidoreductase that functions as a disulfide reductase within the thioredoxin system. It possesses peroxidase and protein-disulfide reductase activities, utilizing a conserved thioredoxin-like active-site motif to undergo reversible dithiol–disulfide exchange. This mechanism allows TXNDC17 to modulate various redox-sensitive targets and signaling pathways, most notably the TNF-α–NF-κB signaling cascade. Additionally, it participates in the redox control of protein-tyrosine phosphatases and the regulation of persulfidated or nitrosylated cysteines. Rather than providing bulk antioxidant defense, TXNDC17 acts as a specific regulator of cellular redox signaling, influencing downstream cellular responses to oxidative stress and inflammatory stimuli.
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技术参数
- 靶点基因名
- TXNDC17
- 基因别名
- TXNL5
- 蛋白别名
- thioredoxin domain containing 17; TXNDC17
- UniProt
- Q9BRA2
- 物种
- Human
产品详情
- 靶点名称
- TXNDC17
- 蛋白名称
- thioredoxin domain containing 17
- 蛋白别名
- Thioredoxin domain-containing protein 17; 14 kDa thioredoxin-related protein; TRP14; Protein 42-9-9; Thioredoxin-like protein 5
- 靶点基因名
- TXNDC17
- 基因别名
- TXNL5
- UniProt
- Q9BRA2
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Thioredoxin domain containing 17 (TXNDC17) is a small, ubiquitously expressed cytosolic oxidoreductase that functions as a disulfide reductase within the thioredoxin system. It possesses peroxidase and protein-disulfide reductase activities, utilizing a conserved thioredoxin-like active-site motif to undergo reversible dithiol–disulfide exchange. This mechanism allows TXNDC17 to modulate various redox-sensitive targets and signaling pathways, most notably the TNF-α–NF-κB signaling cascade. Additionally, it participates in the redox control of protein-tyrosine phosphatases and the regulation of persulfidated or nitrosylated cysteines. Rather than providing bulk antioxidant defense, TXNDC17 acts as a specific regulator of cellular redox signaling, influencing downstream cellular responses to oxidative stress and inflammatory stimuli.