人 TTLL13 抗体对
01AB02351
Tubulin tyrosine ligase like 13 (TTLL13) is a cytosolic polyglutamylase that regulates microtubule modifications by elongating polyglutamate side chains on specific C-terminal glutamate residues of tubulin. It shows a preference for alpha-tubulin and utilizes ATP during the elongation phase of polyglutamylation. TTLL13 localizes to the cytosol and the ciliary basal body, where it participates in the formation of microtubule bundles. Through these activities, it modulates microtubule dynamics and ciliary function, which are essential for cellular structural integrity and intracellular transport. As a member of the tubulin tyrosine ligase-like family, TTLL13 works alongside paralogs such as TTLL6 to maintain the precise patterns of tubulin glutamylation required for proper cytoskeletal architecture.
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技术参数
- 靶点基因名
- TTLL13
- 基因别名
- TTLL13P
- 蛋白别名
- tubulin tyrosine ligase like 13; TTLL13
- UniProt
- A6NNM8
- 物种
- Human
产品详情
- 靶点名称
- TTLL13
- 蛋白名称
- tubulin tyrosine ligase like 13
- 蛋白别名
- Tubulin polyglutamylase TTLL13; Tubulin tyrosine ligase like 13; Tubulin tyrosine ligase-like family member 13 pseudogene; Tubulin--tyrosine ligase-like protein 13
- 靶点基因名
- TTLL13
- 基因别名
- TTLL13P
- UniProt
- A6NNM8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Tubulin tyrosine ligase like 13 (TTLL13) is a cytosolic polyglutamylase that regulates microtubule modifications by elongating polyglutamate side chains on specific C-terminal glutamate residues of tubulin. It shows a preference for alpha-tubulin and utilizes ATP during the elongation phase of polyglutamylation. TTLL13 localizes to the cytosol and the ciliary basal body, where it participates in the formation of microtubule bundles. Through these activities, it modulates microtubule dynamics and ciliary function, which are essential for cellular structural integrity and intracellular transport. As a member of the tubulin tyrosine ligase-like family, TTLL13 works alongside paralogs such as TTLL6 to maintain the precise patterns of tubulin glutamylation required for proper cytoskeletal architecture.