人 TTLL12 抗体对
01AB02348
Tubulin tyrosine ligase-like protein 12 (TTLL12) is a 644-amino acid enzyme belonging to the tubulin tyrosine ligase-like (TTLL) family, primarily involved in regulating post-translational modifications of tubulin, such as detyrosination and polyglutamylation, as well as histone modifications, notably promoting histone H4 trimethylation at lysine 20 (H4K20me3). Structurally, TTLL12 contains a SET-like domain, linked to histone methylation, and a TTL-like domain, associated with tubulin modifications, and is localized in the cytosol and plasma membrane. Functionally, it plays a crucial role in mitotic regulation, chromosome stability, and negatively regulates type I interferon-mediated signaling, particularly during RNA virus infection by modulating the DDX58/RIG-I pathway. Clinically, elevated TTLL12 expression has been correlated with poor prognosis in ovarian cancer, where high levels are associated with advanced disease stage and reduced overall and disease-free survival, suggesting its potential as a prognostic biomarker.
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技术参数
- 靶点基因名
- TTLL12
- 基因别名
- KIAA0153
- 蛋白别名
- tubulin tyrosine ligase like 12; TTLL12
- UniProt
- Q14166
- 物种
- Human
产品详情
- 靶点名称
- TTLL12
- 蛋白名称
- tubulin tyrosine ligase like 12
- 蛋白别名
- Tubulin--tyrosine ligase-like protein 12; Inactive tubulin--tyrosine ligase-like protein 12
- 靶点基因名
- TTLL12
- 基因别名
- KIAA0153
- UniProt
- Q14166
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Tubulin tyrosine ligase-like protein 12 (TTLL12) is a 644-amino acid enzyme belonging to the tubulin tyrosine ligase-like (TTLL) family, primarily involved in regulating post-translational modifications of tubulin, such as detyrosination and polyglutamylation, as well as histone modifications, notably promoting histone H4 trimethylation at lysine 20 (H4K20me3). Structurally, TTLL12 contains a SET-like domain, linked to histone methylation, and a TTL-like domain, associated with tubulin modifications, and is localized in the cytosol and plasma membrane. Functionally, it plays a crucial role in mitotic regulation, chromosome stability, and negatively regulates type I interferon-mediated signaling, particularly during RNA virus infection by modulating the DDX58/RIG-I pathway. Clinically, elevated TTLL12 expression has been correlated with poor prognosis in ovarian cancer, where high levels are associated with advanced disease stage and reduced overall and disease-free survival, suggesting its potential as a prognostic biomarker.