人 Tryptase-I 抗体对
01AB03770
Tryptase alpha/beta-1 (TPSAB1) encodes a serine protease primarily found in mast cells, playing a significant role in inflammatory responses and allergic reactions. This protein exists in two isoforms, alpha and beta, which are over 97% identical, complicating their detection and functional distinction. TPSAB1 is crucial for the release of tryptase from mast cells, which contributes to the degradation of extracellular matrix components and the modulation of immune responses. Dysregulation of TPSAB1 is linked to hereditary alpha tryptasemia, an autosomal dominant condition characterized by elevated serum tryptase levels due to increased gene copies. Individuals with this condition can experience symptoms such as systemic hypersensitivity reactions, gastrointestinal issues, and connective tissue abnormalities.
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技术参数
- 靶点基因名
- TPSAB1
- 基因别名
- TPS1; TPS2; TPSB1
- 蛋白别名
- tryptase alpha/beta 1; Tryptase-I
- UniProt
- Q15661
- 物种
- Human
产品详情
- 靶点名称
- Tryptase-I
- 蛋白名称
- tryptase alpha/beta 1
- 蛋白别名
- Tryptase alpha/beta-1; Tryptase-1; Tryptase I; Tryptase alpha-1
- 靶点基因名
- TPSAB1
- 基因别名
- TPS1; TPS2; TPSB1
- UniProt
- Q15661
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Tryptase alpha/beta-1 (TPSAB1) encodes a serine protease primarily found in mast cells, playing a significant role in inflammatory responses and allergic reactions. This protein exists in two isoforms, alpha and beta, which are over 97% identical, complicating their detection and functional distinction. TPSAB1 is crucial for the release of tryptase from mast cells, which contributes to the degradation of extracellular matrix components and the modulation of immune responses. Dysregulation of TPSAB1 is linked to hereditary alpha tryptasemia, an autosomal dominant condition characterized by elevated serum tryptase levels due to increased gene copies. Individuals with this condition can experience symptoms such as systemic hypersensitivity reactions, gastrointestinal issues, and connective tissue abnormalities.