人 TRPM8 抗体对
01AB02345
Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a voltage-dependent, non-selective cation channel that serves as the primary molecular transducer for environmental cold. It functions as a homotetramer, forming a pore that conducts sodium and calcium ions in response to mild cooling, membrane depolarization, and chemical cooling agents such as menthol. TRPM8 is highly expressed in sensory neurons of the dorsal root and trigeminal ganglia, where it mediates thermal sensation and thermoregulation. Pathophysiologically, the channel is a major contributor to cold allodynia and various chronic pain states. Additionally, TRPM8 is significantly implicated in prostate cancer biology as an androgen-regulated channel, making it a relevant biomarker and potential therapeutic target.
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技术参数
- 靶点基因名
- TRPM8
- 基因别名
- LTRPC6; TRPP8
- 蛋白别名
- transient receptor potential cation channel subfamily M member 8; TRPM8
- UniProt
- Q7Z2W7
- 物种
- Human
产品详情
- 靶点名称
- TRPM8
- 蛋白名称
- transient receptor potential cation channel subfamily M member 8
- 蛋白别名
- Transient receptor potential cation channel subfamily M member 8; Long transient receptor potential channel 6; LTrpC-6; LTrpC6; Transient receptor potential p8; Trp-p8
- 靶点基因名
- TRPM8
- 基因别名
- LTRPC6; TRPP8
- UniProt
- Q7Z2W7
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a voltage-dependent, non-selective cation channel that serves as the primary molecular transducer for environmental cold. It functions as a homotetramer, forming a pore that conducts sodium and calcium ions in response to mild cooling, membrane depolarization, and chemical cooling agents such as menthol. TRPM8 is highly expressed in sensory neurons of the dorsal root and trigeminal ganglia, where it mediates thermal sensation and thermoregulation. Pathophysiologically, the channel is a major contributor to cold allodynia and various chronic pain states. Additionally, TRPM8 is significantly implicated in prostate cancer biology as an androgen-regulated channel, making it a relevant biomarker and potential therapeutic target.