人 TRPC5OS 抗体对
01AB03179
TRPC5 opposite strand (TRPC5OS) is a primate-specific long noncoding RNA that encodes a small, functional intracellular microprotein. While showing restricted expression in normal brain tissue, TRPC5OS acts as an oncogenic factor in triple-negative breast cancer (TNBC). Mechanistically, the encoded microprotein interacts directly with the glycolytic enzyme alpha-enolase (ENO1), increasing its stability and protein levels. This upregulation enhances glycolysis, cell proliferation, and migration, driving tumor growth and colony formation. The TRPC5OS-ENO1 axis represents a specific metabolic vulnerability and potential therapeutic target in aggressive breast cancers.
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技术参数
- 靶点基因名
- TRPC5OS
- 基因别名
- TRPC5-AS1
- 蛋白别名
- TRPC5 opposite strand; TRPC5OS
- UniProt
- A6NMA1
- 物种
- Human
产品详情
- 靶点名称
- TRPC5OS
- 蛋白名称
- TRPC5 opposite strand
- 蛋白别名
- Putative uncharacterized protein TRPC5OS; TRPC5 opposite strand protein; TRPC5-antisense RNA 1
- 靶点基因名
- TRPC5OS
- 基因别名
- TRPC5-AS1
- UniProt
- A6NMA1
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
TRPC5 opposite strand (TRPC5OS) is a primate-specific long noncoding RNA that encodes a small, functional intracellular microprotein. While showing restricted expression in normal brain tissue, TRPC5OS acts as an oncogenic factor in triple-negative breast cancer (TNBC). Mechanistically, the encoded microprotein interacts directly with the glycolytic enzyme alpha-enolase (ENO1), increasing its stability and protein levels. This upregulation enhances glycolysis, cell proliferation, and migration, driving tumor growth and colony formation. The TRPC5OS-ENO1 axis represents a specific metabolic vulnerability and potential therapeutic target in aggressive breast cancers.