人 TrkB 抗体对
01AB02233
Neurotrophic receptor tyrosine kinase 2 (TrkB) is a transmembrane receptor that serves as the high-affinity receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). Upon ligand binding, TrkB undergoes dimerization and autophosphorylation, activating downstream signaling cascades including the MAPK/ERK, PI3K/AKT, and PLCgamma pathways. These signals are essential for regulating neuronal survival, differentiation, synaptic plasticity, and morphology. Alternative splicing produces multiple isoforms, such as the full-length catalytic receptor and truncated versions like TrkB.T1, which modulate ligand availability and signaling. Dysregulation or oncogenic fusion of the NTRK2 gene is implicated in various malignancies, including neuroblastoma and glioma. Furthermore, altered TrkB signaling is associated with neurological and psychiatric conditions such as depression, epilepsy, and neurodegenerative diseases.
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技术参数
- 靶点基因名
- NTRK2
- 基因别名
- TRKB
- 蛋白别名
- neurotrophic receptor tyrosine kinase 2; TrkB
- UniProt
- Q16620
- 物种
- Human
产品详情
- 靶点名称
- TrkB
- 蛋白名称
- neurotrophic receptor tyrosine kinase 2
- 蛋白别名
- BDNF/NT-3 growth factors receptor; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B
- 靶点基因名
- NTRK2
- 基因别名
- TRKB
- UniProt
- Q16620
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Neurotrophic receptor tyrosine kinase 2 (TrkB) is a transmembrane receptor that serves as the high-affinity receptor for brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). Upon ligand binding, TrkB undergoes dimerization and autophosphorylation, activating downstream signaling cascades including the MAPK/ERK, PI3K/AKT, and PLCgamma pathways. These signals are essential for regulating neuronal survival, differentiation, synaptic plasticity, and morphology. Alternative splicing produces multiple isoforms, such as the full-length catalytic receptor and truncated versions like TrkB.T1, which modulate ligand availability and signaling. Dysregulation or oncogenic fusion of the NTRK2 gene is implicated in various malignancies, including neuroblastoma and glioma. Furthermore, altered TrkB signaling is associated with neurological and psychiatric conditions such as depression, epilepsy, and neurodegenerative diseases.