人 TRIO 抗体对
01AB02343
Trio Rho guanine nucleotide exchange factor (TRIO) is a large, multidomain protein that serves as a critical regulator of the actin cytoskeleton, cell migration, and adhesion. It functions as a dual Rho family GEF, utilizing two distinct catalytic units: the N-terminal TrioD1 domain activates Rac1 and RhoG, while the C-terminal TrioD2 domain activates RhoA. This coordinated regulation is essential for neuronal development, axon guidance, and leukocyte transendothelial migration. TRIO also contains spectrin repeats and a serine/threonine kinase domain, supporting its role as a versatile signaling scaffold. Clinically, mutations and dysregulation of TRIO are implicated in the progression of various malignancies, particularly G-alpha-q/11-driven cancers, where the relief of autoinhibition in its RhoA-activating module sustains oncogenic signaling and promotes tumor growth.
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技术参数
- 靶点基因名
- TRIO
- 蛋白别名
- trio Rho guanine nucleotide exchange factor; TRIO
- UniProt
- O75962
- 物种
- Human
产品详情
- 靶点名称
- TRIO
- 蛋白名称
- trio Rho guanine nucleotide exchange factor
- 蛋白别名
- Triple functional domain protein; PTPRF-interacting protein
- 靶点基因名
- TRIO
- UniProt
- O75962
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Trio Rho guanine nucleotide exchange factor (TRIO) is a large, multidomain protein that serves as a critical regulator of the actin cytoskeleton, cell migration, and adhesion. It functions as a dual Rho family GEF, utilizing two distinct catalytic units: the N-terminal TrioD1 domain activates Rac1 and RhoG, while the C-terminal TrioD2 domain activates RhoA. This coordinated regulation is essential for neuronal development, axon guidance, and leukocyte transendothelial migration. TRIO also contains spectrin repeats and a serine/threonine kinase domain, supporting its role as a versatile signaling scaffold. Clinically, mutations and dysregulation of TRIO are implicated in the progression of various malignancies, particularly G-alpha-q/11-driven cancers, where the relief of autoinhibition in its RhoA-activating module sustains oncogenic signaling and promotes tumor growth.