抗人 TRIM5 抗体对
01AB03820
TRIM5 (Tripartite Motif Containing 5) is a crucial protein in the innate immune response, primarily known for its role in restricting retroviral infections, particularly HIV-1. It functions by recognizing and binding to the viral capsid, leading to the disassembly of the virus shortly after entry into the host cell. This antiviral activity is mediated through its RING domain, which also exhibits E3 ubiquitin ligase activity, influencing various signaling pathways involved in immune responses and inflammation. Moreover, polymorphisms in the TRIM5 gene have been associated with variations in HIV-1 infection outcomes, indicating its potential as a genetic factor influencing disease susceptibility. Beyond viral infections, TRIM5 has been implicated in autoimmune diseases such as systemic lupus erythematosus (SLE), where its expression correlates with disease severity, suggesting that it may also modulate immune responses in pathological contexts.
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技术参数
- 靶点基因名
- TRIM5
- 基因别名
- RNF88
- 蛋白别名
- tripartite motif containing 5; TRIM5
- UniProt
- Q9C035
- 物种
- Human
产品详情
- 靶点名称
- TRIM5
- 蛋白名称
- tripartite motif containing 5
- 蛋白别名
- Tripartite motif-containing protein 5; RING finger protein 88; RING-type E3 ubiquitin transferase TRIM5
- 靶点基因名
- TRIM5
- 基因别名
- RNF88
- UniProt
- Q9C035
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
TRIM5 (Tripartite Motif Containing 5) is a crucial protein in the innate immune response, primarily known for its role in restricting retroviral infections, particularly HIV-1. It functions by recognizing and binding to the viral capsid, leading to the disassembly of the virus shortly after entry into the host cell. This antiviral activity is mediated through its RING domain, which also exhibits E3 ubiquitin ligase activity, influencing various signaling pathways involved in immune responses and inflammation. Moreover, polymorphisms in the TRIM5 gene have been associated with variations in HIV-1 infection outcomes, indicating its potential as a genetic factor influencing disease susceptibility. Beyond viral infections, TRIM5 has been implicated in autoimmune diseases such as systemic lupus erythematosus (SLE), where its expression correlates with disease severity, suggesting that it may also modulate immune responses in pathological contexts.