人 TRIM41 抗体对
01AB01612
Tripartite motif containing 41 (TRIM41) is a cytosolic RING-type E3 ubiquitin ligase that plays a pivotal role in innate antiviral immunity and germline development. It utilizes its C-terminal PRY/SPRY domain to recognize substrates, such as the nucleoproteins of influenza A and vesicular stomatitis virus, targeting them for ubiquitination and subsequent degradation to restrict viral infection. TRIM41 also modulates host signaling by ubiquitinating BCL10, thereby enhancing NF-kappaB and IRF3 activation. Beyond its immunological functions, TRIM41 is essential for male meiosis. It regulates the loading of SYCP3 onto chromosome axes and is required for proper XY body formation during spermatogenesis. Clinically, mutations or deletions of TRIM41 are linked to male infertility, as its absence leads to meiotic arrest and defective sperm production, while female fertility remains unaffected.
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技术参数
- 靶点基因名
- TRIM41
- 基因别名
- RINCK
- 蛋白别名
- tripartite motif containing 41; TRIM41
- UniProt
- Q8WV44
- 物种
- Human
产品详情
- 靶点名称
- TRIM41
- 蛋白名称
- tripartite motif containing 41
- 蛋白别名
- E3 ubiquitin-protein ligase TRIM41; RING finger-interacting protein with C kinase; RINCK; Tripartite motif-containing protein 41
- 靶点基因名
- TRIM41
- 基因别名
- RINCK
- UniProt
- Q8WV44
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Tripartite motif containing 41 (TRIM41) is a cytosolic RING-type E3 ubiquitin ligase that plays a pivotal role in innate antiviral immunity and germline development. It utilizes its C-terminal PRY/SPRY domain to recognize substrates, such as the nucleoproteins of influenza A and vesicular stomatitis virus, targeting them for ubiquitination and subsequent degradation to restrict viral infection. TRIM41 also modulates host signaling by ubiquitinating BCL10, thereby enhancing NF-kappaB and IRF3 activation. Beyond its immunological functions, TRIM41 is essential for male meiosis. It regulates the loading of SYCP3 onto chromosome axes and is required for proper XY body formation during spermatogenesis. Clinically, mutations or deletions of TRIM41 are linked to male infertility, as its absence leads to meiotic arrest and defective sperm production, while female fertility remains unaffected.