人 TRIM21 抗体对
01AB03781
E3 ubiquitin-protein ligase TRIM21 (TRIM21) is a multifunctional protein that acts as both an E3 ubiquitin ligase and an intracellular antibody receptor, primarily involved in the immune response against viral infections. It contains several functional domains, including a RING domain that provides E3 ligase activity, which facilitates the ubiquitination and subsequent degradation of target proteins, including viral components. TRIM21 recognizes antibody-coated viruses that have entered the cytosol, triggering a process known as antibody-dependent intracellular neutralization (ADIN), which prevents viral replication and induces an antiviral state within the cell. Dysregulation of TRIM21 has been implicated in various diseases, including autoimmune disorders, where it can act as a self-antigen, leading to the production of autoantibodies.
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技术参数
- 靶点基因名
- TRIM21
- 基因别名
- RNF81; RO52; SSA1
- 蛋白别名
- tripartite motif containing 21; TRIM21
- UniProt
- P19474
- 物种
- Human
产品详情
- 靶点名称
- TRIM21
- 蛋白名称
- tripartite motif containing 21
- 蛋白别名
- E3 ubiquitin-protein ligase TRIM21; 52 kDa Ro protein; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; RING finger protein 81; Ro(SS-A); Sjoegren syndrome type A antigen; SS-A; Tripartite motif-containing protein 21
- 靶点基因名
- TRIM21
- 基因别名
- RNF81; RO52; SSA1
- UniProt
- P19474
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
E3 ubiquitin-protein ligase TRIM21 (TRIM21) is a multifunctional protein that acts as both an E3 ubiquitin ligase and an intracellular antibody receptor, primarily involved in the immune response against viral infections. It contains several functional domains, including a RING domain that provides E3 ligase activity, which facilitates the ubiquitination and subsequent degradation of target proteins, including viral components. TRIM21 recognizes antibody-coated viruses that have entered the cytosol, triggering a process known as antibody-dependent intracellular neutralization (ADIN), which prevents viral replication and induces an antiviral state within the cell. Dysregulation of TRIM21 has been implicated in various diseases, including autoimmune disorders, where it can act as a self-antigen, leading to the production of autoantibodies.