人 TREML1 抗体对
01AB02044
Triggering receptor expressed on myeloid cells like 1 (TREML1), also known as TLT-1, is a transmembrane immunoglobulin superfamily receptor predominantly expressed in megakaryocytes and sequestered in the α-granules of platelets. Upon platelet activation, TREML1 is rapidly translocated to the cell surface, where it binds fibrinogen and acts as a co-stimulatory receptor to enhance platelet aggregation and hemostasis. The receptor contains cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that modulate signaling and can be released as a soluble form (sTLT-1) to regulate inflammatory responses. Clinically, TREML1 is linked to Gray platelet syndrome and various thrombo-inflammatory conditions, including atherosclerosis, sepsis-related coagulopathy, and acute coronary syndromes.
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技术参数
- 靶点基因名
- TREML1
- 基因别名
- TLT1
- 蛋白别名
- triggering receptor expressed on myeloid cells like 1; TREML1
- UniProt
- Q86YW5
- 物种
- Human
产品详情
- 靶点名称
- TREML1
- 蛋白名称
- triggering receptor expressed on myeloid cells like 1
- 蛋白别名
- Trem-like transcript 1 protein; TLT-1; Triggering receptor expressed on myeloid cells-like protein 1
- 靶点基因名
- TREML1
- 基因别名
- TLT1
- UniProt
- Q86YW5
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Triggering receptor expressed on myeloid cells like 1 (TREML1), also known as TLT-1, is a transmembrane immunoglobulin superfamily receptor predominantly expressed in megakaryocytes and sequestered in the α-granules of platelets. Upon platelet activation, TREML1 is rapidly translocated to the cell surface, where it binds fibrinogen and acts as a co-stimulatory receptor to enhance platelet aggregation and hemostasis. The receptor contains cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that modulate signaling and can be released as a soluble form (sTLT-1) to regulate inflammatory responses. Clinically, TREML1 is linked to Gray platelet syndrome and various thrombo-inflammatory conditions, including atherosclerosis, sepsis-related coagulopathy, and acute coronary syndromes.