人 TOP2B 抗体对
01AB03702
DNA topoisomerase 2-beta (TOP2B) is a type II topoisomerase that plays a critical role in managing DNA topology during transcription, replication, and chromosome segregation. It functions by creating transient double-strand breaks in DNA, allowing the strands to pass through each other, which alleviates torsional stress generated during these processes. TOP2B is characterized by its ability to bind ATP and catalyze the cleavage and religation of DNA strands, thus maintaining genomic integrity. Unlike its paralog TOP2A, TOP2B is expressed in both dividing and non-dividing cells and is essential for various cellular functions, including neuronal activity and gene regulation. Dysregulation of TOP2B has been implicated in several diseases, particularly cancer, where its activity can contribute to chromosomal translocations and mutations. Additionally, alterations in TOP2B expression have been linked to neurodevelopmental disorders and other conditions.
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技术参数
- 靶点基因名
- TOP2B
- 蛋白别名
- DNA topoisomerase II beta; TOP2B
- UniProt
- Q02880
- 物种
- Human
产品详情
- 靶点名称
- TOP2B
- 蛋白名称
- DNA topoisomerase II beta
- 蛋白别名
- DNA topoisomerase 2-beta; DNA topoisomerase II; beta isozyme
- 靶点基因名
- TOP2B
- UniProt
- Q02880
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
DNA topoisomerase 2-beta (TOP2B) is a type II topoisomerase that plays a critical role in managing DNA topology during transcription, replication, and chromosome segregation. It functions by creating transient double-strand breaks in DNA, allowing the strands to pass through each other, which alleviates torsional stress generated during these processes. TOP2B is characterized by its ability to bind ATP and catalyze the cleavage and religation of DNA strands, thus maintaining genomic integrity. Unlike its paralog TOP2A, TOP2B is expressed in both dividing and non-dividing cells and is essential for various cellular functions, including neuronal activity and gene regulation. Dysregulation of TOP2B has been implicated in several diseases, particularly cancer, where its activity can contribute to chromosomal translocations and mutations. Additionally, alterations in TOP2B expression have been linked to neurodevelopmental disorders and other conditions.