人 TNR 抗体对
01AB01858
Tenascin R (TNR) is a neural extracellular matrix glycoprotein predominantly expressed in the central nervous system, where it plays a key role in neural development and function. Structurally, TNR is the smallest member of the tenascin family, comprising an N-terminal cysteine-rich segment, 4.5 EGF-like repeats, nine fibronectin type III domains, and a C-terminal fibrinogen-like domain, allowing it to form oligomeric structures such as trimers and dimers. TNR localizes to perineuronal nets and nodes of Ranvier, interacting with other extracellular matrix components and cell adhesion molecules, and modulates neural cell adhesion, axon guidance, and neurite outgrowth, often providing only weak adhesion or even repelling axons. Functionally, TNR is essential for the normal development of perineuronal nets and proper conduction velocity in optic nerves, as evidenced by TNR-deficient mice showing disrupted perineuronal net structure and reduced nerve conduction speed. Clinically, mutations in the TNR gene are associated with neurodevelopmental disorders characterized by nonprogressive spasticity and transient motor deficits, highlighting its importance in neural integrity and signaling.
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技术参数
- 靶点基因名
- TNR
- 蛋白别名
- tenascin R; TNR
- UniProt
- Q92752
- 物种
- Human
产品详情
- 靶点名称
- TNR
- 蛋白名称
- tenascin R
- 蛋白别名
- Tenascin-R; TN-R; Janusin; Restrictin
- 靶点基因名
- TNR
- UniProt
- Q92752
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Tenascin R (TNR) is a neural extracellular matrix glycoprotein predominantly expressed in the central nervous system, where it plays a key role in neural development and function. Structurally, TNR is the smallest member of the tenascin family, comprising an N-terminal cysteine-rich segment, 4.5 EGF-like repeats, nine fibronectin type III domains, and a C-terminal fibrinogen-like domain, allowing it to form oligomeric structures such as trimers and dimers. TNR localizes to perineuronal nets and nodes of Ranvier, interacting with other extracellular matrix components and cell adhesion molecules, and modulates neural cell adhesion, axon guidance, and neurite outgrowth, often providing only weak adhesion or even repelling axons. Functionally, TNR is essential for the normal development of perineuronal nets and proper conduction velocity in optic nerves, as evidenced by TNR-deficient mice showing disrupted perineuronal net structure and reduced nerve conduction speed. Clinically, mutations in the TNR gene are associated with neurodevelopmental disorders characterized by nonprogressive spasticity and transient motor deficits, highlighting its importance in neural integrity and signaling.