人 TNFSF14 抗体对
01AB04165
Tumor necrosis factor ligand superfamily member 14 (TNFSF14), also known as LIGHT, is a cytokine that plays a crucial role in immune regulation and inflammation. It functions as a ligand for the TNF receptor superfamily member 14 (TNFRSF14), also known as HVEM, and is involved in T cell activation, proliferation, and cytokine production. TNFSF14 has been shown to promote apoptosis in tumor cells and can inhibit tumor necrosis factor-alpha (TNF-α)-mediated apoptosis in hepatocytes. Dysregulation of TNFSF14 is associated with several diseases, including rheumatoid arthritis and inflammatory bowel disease, where its altered signaling contributes to chronic inflammation. Additionally, elevated levels of TNFSF14 have been linked to certain cancers, such as diffuse large B-cell lymphoma, highlighting its potential role in tumorigenesis.
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技术参数
- 靶点基因名
- TNFSF14
- 基因别名
- HVEML; LIGHT
- 蛋白别名
- TNF superfamily member 14; TNFSF14
- UniProt
- O43557
- 物种
- Human
产品详情
- 靶点名称
- TNFSF14
- 蛋白名称
- TNF superfamily member 14
- 蛋白别名
- Tumor necrosis factor ligand superfamily member 14; Herpes virus entry mediator ligand; HVEM-L; Herpesvirus entry mediator ligand; CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14; membrane form; Tumor necrosis factor ligand superfamily member 14; soluble form]
- 靶点基因名
- TNFSF14
- 基因别名
- HVEML; LIGHT
- UniProt
- O43557
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Tumor necrosis factor ligand superfamily member 14 (TNFSF14), also known as LIGHT, is a cytokine that plays a crucial role in immune regulation and inflammation. It functions as a ligand for the TNF receptor superfamily member 14 (TNFRSF14), also known as HVEM, and is involved in T cell activation, proliferation, and cytokine production. TNFSF14 has been shown to promote apoptosis in tumor cells and can inhibit tumor necrosis factor-alpha (TNF-α)-mediated apoptosis in hepatocytes. Dysregulation of TNFSF14 is associated with several diseases, including rheumatoid arthritis and inflammatory bowel disease, where its altered signaling contributes to chronic inflammation. Additionally, elevated levels of TNFSF14 have been linked to certain cancers, such as diffuse large B-cell lymphoma, highlighting its potential role in tumorigenesis.