人 TNFSF13B 抗体对
01AB00436
TNF superfamily member 13b (TNFSF13B), also known as B-cell activating factor (BAFF), is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is encoded by the TNFSF13B gene located on chromosome 13q33.3. This protein acts as a potent B cell activator, playing a crucial role in the proliferation and differentiation of B cells. It is expressed in B cell lineage cells and interacts with receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. BAFF is involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. Abnormal expression of BAFF has been associated with autoimmune diseases and certain types of cancers, such as chronic lymphocytic leukemia, B-cell lymphoma, and multiple myeloma. The protein exists in both membrane-bound and soluble forms, with the soluble form being generated through cleavage from the membrane-bound form.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- TNFSF13B
- 基因别名
- BAFF; BLYS; TALL1; TNFSF20; ZTNF4
- 蛋白别名
- TNF superfamily member 13b; TNFSF13B
- UniProt
- Q9Y275
- 物种
- Human
产品详情
- 靶点名称
- TNFSF13B
- 蛋白名称
- TNF superfamily member 13b
- 蛋白别名
- Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b; membrane form; Tumor necrosis factor ligand superfamily member 13b; soluble form]
- 靶点基因名
- TNFSF13B
- 基因别名
- BAFF; BLYS; TALL1; TNFSF20; ZTNF4
- UniProt
- Q9Y275
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
TNF superfamily member 13b (TNFSF13B), also known as B-cell activating factor (BAFF), is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is encoded by the TNFSF13B gene located on chromosome 13q33.3. This protein acts as a potent B cell activator, playing a crucial role in the proliferation and differentiation of B cells. It is expressed in B cell lineage cells and interacts with receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. BAFF is involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. Abnormal expression of BAFF has been associated with autoimmune diseases and certain types of cancers, such as chronic lymphocytic leukemia, B-cell lymphoma, and multiple myeloma. The protein exists in both membrane-bound and soluble forms, with the soluble form being generated through cleavage from the membrane-bound form.