抗人 TNFSF11 抗体对
01AB01385
TNF superfamily member 11 (TNFSF11), also known as Tumor necrosis factor ligand superfamily member 11, is a member of the TNF cytokine family that functions as a key regulator in various biological processes. It serves as a ligand for osteoprotegerin and plays a crucial role in osteoclast differentiation and activation. TNFSF11 acts as a dendritic cell survival factor and regulates T-cell-dependent immune responses, with T cell activation inducing its expression. The protein enables identical protein binding activity, receptor ligand activity, and tumor necrosis factor receptor superfamily binding. TNFSF11 activates the antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and TRAF6, suggesting a role in cell apoptosis regulation. Regarding disease associations, disruption of TNFSF11 in mice results in severe osteopetrosis and absence of osteoclasts, along with defects in early T and B lymphocyte differentiation. Additionally, TNFSF11 overexpression can lead to increased osteoclastogenesis and bone loss, making it a significant factor in bone-related disorders.
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技术参数
- 靶点基因名
- TNFSF11
- 基因别名
- OPGL; RANKL; TRANCE
- 蛋白别名
- TNF superfamily member 11; TNFSF11
- UniProt
- O14788
- 物种
- Human
产品详情
- 靶点名称
- TNFSF11
- 蛋白名称
- TNF superfamily member 11
- 蛋白别名
- Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11; membrane form; Tumor necrosis factor ligand superfamily member 11; soluble form]
- 靶点基因名
- TNFSF11
- 基因别名
- OPGL; RANKL; TRANCE
- UniProt
- O14788
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
TNF superfamily member 11 (TNFSF11), also known as Tumor necrosis factor ligand superfamily member 11, is a member of the TNF cytokine family that functions as a key regulator in various biological processes. It serves as a ligand for osteoprotegerin and plays a crucial role in osteoclast differentiation and activation. TNFSF11 acts as a dendritic cell survival factor and regulates T-cell-dependent immune responses, with T cell activation inducing its expression. The protein enables identical protein binding activity, receptor ligand activity, and tumor necrosis factor receptor superfamily binding. TNFSF11 activates the antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and TRAF6, suggesting a role in cell apoptosis regulation. Regarding disease associations, disruption of TNFSF11 in mice results in severe osteopetrosis and absence of osteoclasts, along with defects in early T and B lymphocyte differentiation. Additionally, TNFSF11 overexpression can lead to increased osteoclastogenesis and bone loss, making it a significant factor in bone-related disorders.