人 TNFSF10 抗体对
01AB00435
TNF superfamily member 10 (TNFSF10), also known as TRAIL, is a cytokine that belongs to the tumor necrosis factor ligand family. It is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members. TNFSF10 preferentially induces apoptosis in transformed and tumor cells by binding to several TNF receptor superfamily members, including TNFRSF10A/TRAILR1 and TNFRSF10B/TRAILR2. Its activity can be modulated by binding to decoy receptors TNFRSF10C/TRAILR3 and TNFRSF10D/TRAILR4. TNFSF10 triggers the activation of MAPK8/JNK, caspase 8, and caspase 3, leading to apoptosis. In terms of disease associations, TNFSF10 has been implicated in various cancers, including colorectal and pancreatic cancer, due to its role in tumor cell apoptosis.
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技术参数
- 靶点基因名
- TNFSF10
- 基因别名
- APO2L; TRAIL
- 蛋白别名
- TNF superfamily member 10; TNFSF10
- UniProt
- P50591
- 物种
- Human
产品详情
- 靶点名称
- TNFSF10
- 蛋白名称
- TNF superfamily member 10
- 蛋白别名
- Tumor necrosis factor ligand superfamily member 10; Apo-2 ligand; Apo-2L; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD antigen CD253
- 靶点基因名
- TNFSF10
- 基因别名
- APO2L; TRAIL
- UniProt
- P50591
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
TNF superfamily member 10 (TNFSF10), also known as TRAIL, is a cytokine that belongs to the tumor necrosis factor ligand family. It is a type II transmembrane protein with a carboxy-terminal extracellular domain that exhibits homology to other TNF superfamily members. TNFSF10 preferentially induces apoptosis in transformed and tumor cells by binding to several TNF receptor superfamily members, including TNFRSF10A/TRAILR1 and TNFRSF10B/TRAILR2. Its activity can be modulated by binding to decoy receptors TNFRSF10C/TRAILR3 and TNFRSF10D/TRAILR4. TNFSF10 triggers the activation of MAPK8/JNK, caspase 8, and caspase 3, leading to apoptosis. In terms of disease associations, TNFSF10 has been implicated in various cancers, including colorectal and pancreatic cancer, due to its role in tumor cell apoptosis.