人 TNF 抗体对
01AB02862
Tumor necrosis factor (TNF) is a cytokine that plays a crucial role in the body's immune response and inflammation. It is primarily produced by macrophages and other immune cells to fight off infections and promote tissue repair.However, excessive or prolonged production of TNF can lead to chronic inflammation and various autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, and ankylosing spondylitis.TNF triggers the release of other inflammatory molecules, contributing to joint damage, cartilage destruction, and the painful symptoms associated with these conditions. While TNF is essential for immune defense, its dysregulation can drive pathogenic inflammation, making it a therapeutic target for managing autoimmune and inflammatory disorders through TNF inhibitors.
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技术参数
- 靶点基因名
- TNF
- 基因别名
- TNFA; TNFSF2
- 蛋白别名
- tumor necrosis factor; TNF
- UniProt
- P01375
- 物种
- Human
产品详情
- 靶点名称
- TNF
- 蛋白名称
- tumor necrosis factor
- 蛋白别名
- Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a) [Cleaved into: Tumor necrosis factor; membrane form; N-terminal fragment; NTF; Intracellular domain 1; ICD1; Intracellular domain 2; ICD2; C-domain 1; C-domain 2; Tumor necrosis factor; soluble form]
- 靶点基因名
- TNF
- 基因别名
- TNFA; TNFSF2
- UniProt
- P01375
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Tumor necrosis factor (TNF) is a cytokine that plays a crucial role in the body's immune response and inflammation. It is primarily produced by macrophages and other immune cells to fight off infections and promote tissue repair.However, excessive or prolonged production of TNF can lead to chronic inflammation and various autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, and ankylosing spondylitis.TNF triggers the release of other inflammatory molecules, contributing to joint damage, cartilage destruction, and the painful symptoms associated with these conditions. While TNF is essential for immune defense, its dysregulation can drive pathogenic inflammation, making it a therapeutic target for managing autoimmune and inflammatory disorders through TNF inhibitors.