人 TMPRSS15 抗体对
01AB03699
Enteropeptidase (TMPRSS15) is a type II transmembrane serine protease that plays a crucial role in the digestive process by converting trypsinogen into its active form, trypsin. This activation is essential for the subsequent activation of other pancreatic zymogens, facilitating nutrient digestion and absorption in the small intestine. Enteropeptidase is primarily expressed in the duodenum and jejunum, where it is localized to the brush border of enterocytes. Mutations in the TMPRSS15 can lead to enteropeptidase deficiency, a rare genetic disorder that results in severe malabsorption and failure to thrive in infants due to the inability to activate trypsinogen. Additionally, enteropeptidase has been implicated in pancreatic diseases, including acute necrotizing pancreatitis, where its dysregulation can lead to inappropriate activation of digestive enzymes within the pancreas, causing inflammation and damage.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- TMPRSS15
- 基因别名
- ENTK; PRSS7
- 蛋白别名
- transmembrane serine protease 15; TMPRSS15
- UniProt
- P98073
- 物种
- Human
产品详情
- 靶点名称
- TMPRSS15
- 蛋白名称
- transmembrane serine protease 15
- 蛋白别名
- Enteropeptidase; Enterokinase; Serine protease 7; Transmembrane protease serine 15) [Cleaved into: Enteropeptidase non-catalytic heavy chain; Enteropeptidase catalytic light chain]
- 靶点基因名
- TMPRSS15
- 基因别名
- ENTK; PRSS7
- UniProt
- P98073
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Enteropeptidase (TMPRSS15) is a type II transmembrane serine protease that plays a crucial role in the digestive process by converting trypsinogen into its active form, trypsin. This activation is essential for the subsequent activation of other pancreatic zymogens, facilitating nutrient digestion and absorption in the small intestine. Enteropeptidase is primarily expressed in the duodenum and jejunum, where it is localized to the brush border of enterocytes. Mutations in the TMPRSS15 can lead to enteropeptidase deficiency, a rare genetic disorder that results in severe malabsorption and failure to thrive in infants due to the inability to activate trypsinogen. Additionally, enteropeptidase has been implicated in pancreatic diseases, including acute necrotizing pancreatitis, where its dysregulation can lead to inappropriate activation of digestive enzymes within the pancreas, causing inflammation and damage.