人 THSD1 抗体对
01AB00603
THSD1 is a protein encoded by the THSD1 gene, which contains a type 1 thrombospondin domain found in proteins involved in the complement pathway and extracellular matrix. It is a type I transmembrane protein with a 388 amino acid extracellular region, a 21 amino acid transmembrane region, and a 418 amino acid cytoplasmic region, featuring six potential N-linked glycosylation sites, a thrombospondin type-1 (TSP1) domain, and three Ig-like domains. THSD1 is highly expressed in hematopoietic stem cells (HSCs) and progenitor cells, and it is postulated to play a role in the regulation of vasculogenesis and/or angiogenesis, as well as in HSC homing to the bone marrow niche. Mutations in THSD1 have been associated with intracranial aneurysms and subarachnoid hemorrhage, indicating its critical role in endothelial cell adhesion to the extracellular matrix.
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技术参数
- 靶点基因名
- THSD1
- 基因别名
- TMTSP
- 蛋白别名
- thrombospondin type 1 domain containing 1; THSD1
- UniProt
- Q9NS62
- 物种
- Human
产品详情
- 靶点名称
- THSD1
- 蛋白名称
- thrombospondin type 1 domain containing 1
- 蛋白别名
- Thrombospondin type-1 domain-containing protein 1; Transmembrane molecule with thrombospondin module
- 靶点基因名
- THSD1
- 基因别名
- TMTSP
- UniProt
- Q9NS62
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
THSD1 is a protein encoded by the THSD1 gene, which contains a type 1 thrombospondin domain found in proteins involved in the complement pathway and extracellular matrix. It is a type I transmembrane protein with a 388 amino acid extracellular region, a 21 amino acid transmembrane region, and a 418 amino acid cytoplasmic region, featuring six potential N-linked glycosylation sites, a thrombospondin type-1 (TSP1) domain, and three Ig-like domains. THSD1 is highly expressed in hematopoietic stem cells (HSCs) and progenitor cells, and it is postulated to play a role in the regulation of vasculogenesis and/or angiogenesis, as well as in HSC homing to the bone marrow niche. Mutations in THSD1 have been associated with intracranial aneurysms and subarachnoid hemorrhage, indicating its critical role in endothelial cell adhesion to the extracellular matrix.