人 THPO 抗体对
01AB02906
The THPO gene encodes thrombopoietin, a cytokine that is essential for the production and maturation of platelets from megakaryocytes in the bone marrow. Thrombopoietin stimulates megakaryocyte proliferation and differentiation, and its levels are inversely regulated by circulating platelets. Biallelic loss-of-function mutations in THPO cause severe thrombocytopenia and bone marrow failure (congenital amegakaryocytic thrombocytopenia-2, CAMT2). In contrast, monoallelic loss-of-function variants lead to reduced thrombopoietin secretion and autosomal-dominant thrombocytopenia without affecting other blood cell lineages. THPO binds to the MPL receptor on megakaryocytes, promoting their maturation and platelet formation. Genetic mutations in the THPO gene can lead to disorders such as essential thrombocythemia and congenital amegakaryocytic thrombocytopenia.
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技术参数
- 靶点基因名
- THPO
- 基因别名
- MGDF
- 蛋白别名
- thrombopoietin; THPO
- UniProt
- P40225
- 物种
- Human
产品详情
- 靶点名称
- THPO
- 蛋白名称
- thrombopoietin
- 蛋白别名
- Thrombopoietin; C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand
- 靶点基因名
- THPO
- 基因别名
- MGDF
- UniProt
- P40225
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
The THPO gene encodes thrombopoietin, a cytokine that is essential for the production and maturation of platelets from megakaryocytes in the bone marrow. Thrombopoietin stimulates megakaryocyte proliferation and differentiation, and its levels are inversely regulated by circulating platelets. Biallelic loss-of-function mutations in THPO cause severe thrombocytopenia and bone marrow failure (congenital amegakaryocytic thrombocytopenia-2, CAMT2). In contrast, monoallelic loss-of-function variants lead to reduced thrombopoietin secretion and autosomal-dominant thrombocytopenia without affecting other blood cell lineages. THPO binds to the MPL receptor on megakaryocytes, promoting their maturation and platelet formation. Genetic mutations in the THPO gene can lead to disorders such as essential thrombocythemia and congenital amegakaryocytic thrombocytopenia.