人 THBS4 抗体对
01AB00426
Thrombospondin 4 (THBS4) is a non-structural extracellular matrix protein encoded by the THBS4 gene, belonging to the thrombospondin family known for mediating cell-to-cell and cell-to-matrix interactions. THBS4 plays critical roles in tissue remodeling, angiogenesis, and cell proliferation, particularly in response to injury or stress. The protein forms a pentamer and binds calcium and heparin, facilitating its diverse functions in different tissues. Its unique properties differentiate it from other thrombospondins, contributing to both pro-angiogenic and pro-inflammatory processes in pathological contexts. It has been implicated in various diseases, notably cardiovascular conditions such as myocardial infarction, heart failure, and atherosclerosis, where its expression increases significantly during tissue damage and repair. Additionally, THBS4 is associated with cancer progression due to its ability to enhance cell migration and proliferation via pathways like AKT signaling.
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技术参数
- 靶点基因名
- THBS4
- 基因别名
- TSP4
- 蛋白别名
- thrombospondin 4; THBS4
- UniProt
- P35443
- 物种
- Human
产品详情
- 靶点名称
- THBS4
- 蛋白名称
- thrombospondin 4
- 蛋白别名
- Thrombospondin-4
- 靶点基因名
- THBS4
- 基因别名
- TSP4
- UniProt
- P35443
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Thrombospondin 4 (THBS4) is a non-structural extracellular matrix protein encoded by the THBS4 gene, belonging to the thrombospondin family known for mediating cell-to-cell and cell-to-matrix interactions. THBS4 plays critical roles in tissue remodeling, angiogenesis, and cell proliferation, particularly in response to injury or stress. The protein forms a pentamer and binds calcium and heparin, facilitating its diverse functions in different tissues. Its unique properties differentiate it from other thrombospondins, contributing to both pro-angiogenic and pro-inflammatory processes in pathological contexts. It has been implicated in various diseases, notably cardiovascular conditions such as myocardial infarction, heart failure, and atherosclerosis, where its expression increases significantly during tissue damage and repair. Additionally, THBS4 is associated with cancer progression due to its ability to enhance cell migration and proliferation via pathways like AKT signaling.