人 TGFBR3 抗体对
01AB01610
Transforming growth factor beta receptor 3 (TGFBR3), also known as betaglycan, is a cell surface proteoglycan that binds various members of the TGF-beta superfamily. It is the most widely expressed TGF-beta receptor, with high affinity for all TGF-beta isoforms. TGFBR3 functions as a co-receptor, facilitating ligand binding to other TGF-beta receptors, and can exist in membrane-bound and soluble forms. The protein plays crucial roles in cell proliferation, differentiation, migration, and apoptosis. Its extracellular domain contains two TGF-beta binding sites, while the cytoplasmic domain interacts with scaffold proteins. TGFBR3 is essential for organ development and overall viability, as demonstrated in mouse knockout studies. In disease contexts, decreased TGFBR3 expression has been observed in various cancers, suggesting a potential tumor suppressor role. Additionally, TGFBR3 may be involved in the pathogenesis of systemic sclerosis and Marfan syndrome.
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技术参数
- 靶点基因名
- TGFBR3
- 蛋白别名
- transforming growth factor beta receptor 3; TGFBR3
- UniProt
- Q03167
- 物种
- Human
产品详情
- 靶点名称
- TGFBR3
- 蛋白名称
- transforming growth factor beta receptor 3
- 蛋白别名
- Transforming growth factor beta receptor type 3; TGF-beta receptor type 3; TGFR-3; Betaglycan; Transforming growth factor beta receptor III; TGF-beta receptor type III
- 靶点基因名
- TGFBR3
- UniProt
- Q03167
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Transforming growth factor beta receptor 3 (TGFBR3), also known as betaglycan, is a cell surface proteoglycan that binds various members of the TGF-beta superfamily. It is the most widely expressed TGF-beta receptor, with high affinity for all TGF-beta isoforms. TGFBR3 functions as a co-receptor, facilitating ligand binding to other TGF-beta receptors, and can exist in membrane-bound and soluble forms. The protein plays crucial roles in cell proliferation, differentiation, migration, and apoptosis. Its extracellular domain contains two TGF-beta binding sites, while the cytoplasmic domain interacts with scaffold proteins. TGFBR3 is essential for organ development and overall viability, as demonstrated in mouse knockout studies. In disease contexts, decreased TGFBR3 expression has been observed in various cancers, suggesting a potential tumor suppressor role. Additionally, TGFBR3 may be involved in the pathogenesis of systemic sclerosis and Marfan syndrome.