人 TGFBR1 抗体对
01AB03288
Transforming growth factor beta receptor 1 (TGFBR1), or ALK5, is the type I receptor serine/threonine kinase of the TGF-beta signaling pathway. Upon ligand binding, it forms a complex with type II receptors and phosphorylates SMAD proteins to regulate cell proliferation, differentiation, and apoptosis. TGFBR1 exerts tumor-suppressive effects by inhibiting uncontrolled cell growth, though dysregulated signaling can promote tumorigenesis in advanced cancers. Germline loss-of-function mutations in TGFBR1 cause Loeys-Dietz syndrome, a connective tissue disorder characterized by arterial aneurysms and craniofacial anomalies. Somatic mutations are also found in various cancers.
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技术参数
- 靶点基因名
- TGFBR1
- 基因别名
- ALK5; SKR4
- 蛋白别名
- transforming growth factor beta receptor 1; TGFBR1
- UniProt
- P36897
- 物种
- Human
产品详情
- 靶点名称
- TGFBR1
- 蛋白名称
- transforming growth factor beta receptor 1
- 蛋白别名
- TGF-beta receptor type-1; TGFR-1; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ALK5; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I
- 靶点基因名
- TGFBR1
- 基因别名
- ALK5; SKR4
- UniProt
- P36897
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Transforming growth factor beta receptor 1 (TGFBR1), or ALK5, is the type I receptor serine/threonine kinase of the TGF-beta signaling pathway. Upon ligand binding, it forms a complex with type II receptors and phosphorylates SMAD proteins to regulate cell proliferation, differentiation, and apoptosis. TGFBR1 exerts tumor-suppressive effects by inhibiting uncontrolled cell growth, though dysregulated signaling can promote tumorigenesis in advanced cancers. Germline loss-of-function mutations in TGFBR1 cause Loeys-Dietz syndrome, a connective tissue disorder characterized by arterial aneurysms and craniofacial anomalies. Somatic mutations are also found in various cancers.