人 TGFA 抗体对
01AB02457
Transforming growth factor-alpha (TGFA) is a potent growth factor that plays a significant role in cell proliferation, differentiation, and tissue repair. It is synthesized as a precursor protein and is involved in various physiological processes, including wound healing and tissue regeneration. TGFA functions by activating the epidermal growth factor receptor (EGFR), leading to downstream signaling that promotes cellular growth and survival. Dysregulation of TGFA has been implicated in several diseases, particularly in cancer, where its overexpression can contribute to tumor growth and metastasis. Elevated levels of TGFA have been observed in various malignancies, including breast and lung cancers, where it may facilitate angiogenesis and immune evasion. Additionally, TGFA has been associated with inflammatory conditions such as chronic obstructive pulmonary disease (COPD) and liver fibrosis.
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技术参数
- 靶点基因名
- TGFA
- 蛋白别名
- transforming growth factor alpha; TGFA
- UniProt
- P01135
- 物种
- Human
产品详情
- 靶点名称
- TGFA
- 蛋白名称
- transforming growth factor alpha
- 蛋白别名
- Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha; TGF-alpha; EGF-like TGF; ETGF; TGF type 1]
- 靶点基因名
- TGFA
- UniProt
- P01135
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Transforming growth factor-alpha (TGFA) is a potent growth factor that plays a significant role in cell proliferation, differentiation, and tissue repair. It is synthesized as a precursor protein and is involved in various physiological processes, including wound healing and tissue regeneration. TGFA functions by activating the epidermal growth factor receptor (EGFR), leading to downstream signaling that promotes cellular growth and survival. Dysregulation of TGFA has been implicated in several diseases, particularly in cancer, where its overexpression can contribute to tumor growth and metastasis. Elevated levels of TGFA have been observed in various malignancies, including breast and lung cancers, where it may facilitate angiogenesis and immune evasion. Additionally, TGFA has been associated with inflammatory conditions such as chronic obstructive pulmonary disease (COPD) and liver fibrosis.