人 TES 抗体对
01AB02904
Testin LIM domain protein (TES) is a cytoskeletal scaffold protein comprising an N-terminal PET domain and three C-terminal LIM zinc-finger domains. It localizes to focal adhesions and actin stress fibers, where it regulates cell spreading, motility, and cytoskeletal reorganization. Functioning as a tumor suppressor, TES negatively regulates cell proliferation and is frequently silenced in malignancies—including ovarian, breast, and gastric cancers—via promoter hypermethylation and loss of heterozygosity. Reduced TES expression correlates with epithelial-mesenchymal transition (EMT) and poor prognosis, suggesting its potential utility as a biomarker for cancer progression and therapeutic response.
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技术参数
- 靶点基因名
- TES
- 蛋白别名
- testin LIM domain protein; TES
- UniProt
- Q9UGI8
- 物种
- Human
产品详情
- 靶点名称
- TES
- 蛋白名称
- testin LIM domain protein
- 蛋白别名
- Testin; TESS
- 靶点基因名
- TES
- UniProt
- Q9UGI8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Testin LIM domain protein (TES) is a cytoskeletal scaffold protein comprising an N-terminal PET domain and three C-terminal LIM zinc-finger domains. It localizes to focal adhesions and actin stress fibers, where it regulates cell spreading, motility, and cytoskeletal reorganization. Functioning as a tumor suppressor, TES negatively regulates cell proliferation and is frequently silenced in malignancies—including ovarian, breast, and gastric cancers—via promoter hypermethylation and loss of heterozygosity. Reduced TES expression correlates with epithelial-mesenchymal transition (EMT) and poor prognosis, suggesting its potential utility as a biomarker for cancer progression and therapeutic response.