人 TERF1 抗体对
01AB00422
Telomeric repeat binding factor 1 (TERF1), also known as TRF1, is a crucial protein involved in the maintenance of telomeres, the protective caps at the ends of chromosomes. It binds to the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length by acting as an inhibitor of telomerase, limiting the elongation of individual telomeres. TERF1 is part of the Shelterin complex, which includes other proteins such as TRF2, Rap1, POT1, TIN2, and TPP1, and plays a role in the regulation of the mitotic spindle. The protein contains a MYB-type helix-turn-helix DNA-binding domain and a TRF-homology domain, which are essential for its function. Dysregulation of TERF1 has been implicated in various diseases, including cancer, where altered telomere length can lead to genomic instability.
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技术参数
- 靶点基因名
- TERF1
- 基因别名
- PIN2; TRBF1; TRF; TRF1
- 蛋白别名
- telomeric repeat binding factor 1; TERF1
- UniProt
- P54274
- 物种
- Human
产品详情
- 靶点名称
- TERF1
- 蛋白名称
- telomeric repeat binding factor 1
- 蛋白别名
- Telomeric repeat-binding factor 1; NIMA-interacting protein 2; TTAGGG repeat-binding factor 1; Telomeric protein Pin2/TRF1
- 靶点基因名
- TERF1
- 基因别名
- PIN2; TRBF1; TRF; TRF1
- UniProt
- P54274
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Telomeric repeat binding factor 1 (TERF1), also known as TRF1, is a crucial protein involved in the maintenance of telomeres, the protective caps at the ends of chromosomes. It binds to the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length by acting as an inhibitor of telomerase, limiting the elongation of individual telomeres. TERF1 is part of the Shelterin complex, which includes other proteins such as TRF2, Rap1, POT1, TIN2, and TPP1, and plays a role in the regulation of the mitotic spindle. The protein contains a MYB-type helix-turn-helix DNA-binding domain and a TRF-homology domain, which are essential for its function. Dysregulation of TERF1 has been implicated in various diseases, including cancer, where altered telomere length can lead to genomic instability.