人 TEC 抗体对
01AB02320
Tec protein tyrosine kinase (TEC) is a non-receptor tyrosine kinase and the founding member of the Tec family. It is primarily expressed in hematopoietic cells, where it integrates signals from antigen receptors, cytokine receptors, and integrins to regulate calcium signaling, gene transcription, and cell survival. Structurally, TEC contains PH, TH, SH3, and SH2 domains that facilitate its recruitment to the plasma membrane via PI3K-generated PIP3. It plays a critical role in T-cell and B-cell activation, as well as platelet signaling. Clinically, altered TEC activity is linked to immune dysregulation and chronic inflammation. Additionally, TEC exhibits cardioprotective roles during ischemic heart injury through its interactions with HIF-1α and ROCK1, highlighting its importance in stress-activated signaling pathways.
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技术参数
- 靶点基因名
- TEC
- 基因别名
- PSCTK4
- 蛋白别名
- tec protein tyrosine kinase; TEC
- UniProt
- P42680
- 物种
- Human
产品详情
- 靶点名称
- TEC
- 蛋白名称
- tec protein tyrosine kinase
- 蛋白别名
- Tyrosine-protein kinase Tec
- 靶点基因名
- TEC
- 基因别名
- PSCTK4
- UniProt
- P42680
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Tec protein tyrosine kinase (TEC) is a non-receptor tyrosine kinase and the founding member of the Tec family. It is primarily expressed in hematopoietic cells, where it integrates signals from antigen receptors, cytokine receptors, and integrins to regulate calcium signaling, gene transcription, and cell survival. Structurally, TEC contains PH, TH, SH3, and SH2 domains that facilitate its recruitment to the plasma membrane via PI3K-generated PIP3. It plays a critical role in T-cell and B-cell activation, as well as platelet signaling. Clinically, altered TEC activity is linked to immune dysregulation and chronic inflammation. Additionally, TEC exhibits cardioprotective roles during ischemic heart injury through its interactions with HIF-1α and ROCK1, highlighting its importance in stress-activated signaling pathways.