人 TCL1B 抗体对
01AB00420
TCL1 family AKT coactivator B (TCL1B), or T-cell leukemia/lymphoma protein 1B, is a protein encoded by the TCL1B gene in humans. It functions as an AKT kinase co-activator, enhancing the phosphorylation and activation of AKT1 and AKT2. TCL1B exhibits protein kinase binding activity and protein serine/threonine kinase activator activity, playing a role in intracellular signal transduction. The protein is involved in positive regulation of peptidyl-serine phosphorylation and protein kinase B signaling. TCL1B is expressed in CD4-/CD8- immature T-cells, pre B-cells, and virgin B-cells, with expression decreasing at more mature stages of B-cell development. Overexpression of TCL1B has been implicated in the development of mature T-cell leukemia, with chromosomal rearrangements bringing the gene in close proximity to T-cell antigen receptor regulatory elements. Additionally, TCL1B has been associated with lymphatic system diseases and immune system disorders.
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技术参数
- 靶点基因名
- TCL1B
- 基因别名
- TCL1
- 蛋白别名
- TCL1 family AKT coactivator B; TCL1B
- UniProt
- O95988
- 物种
- Human
产品详情
- 靶点名称
- TCL1B
- 蛋白名称
- TCL1 family AKT coactivator B
- 蛋白别名
- T-cell leukemia/lymphoma protein 1B; Oncogene TCL-1B; Oncogene TCL1B; SYN-1; Syncytiotrophoblast-specific protein; TCL1/MTCP1-like protein 1
- 靶点基因名
- TCL1B
- 基因别名
- TCL1
- UniProt
- O95988
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
TCL1 family AKT coactivator B (TCL1B), or T-cell leukemia/lymphoma protein 1B, is a protein encoded by the TCL1B gene in humans. It functions as an AKT kinase co-activator, enhancing the phosphorylation and activation of AKT1 and AKT2. TCL1B exhibits protein kinase binding activity and protein serine/threonine kinase activator activity, playing a role in intracellular signal transduction. The protein is involved in positive regulation of peptidyl-serine phosphorylation and protein kinase B signaling. TCL1B is expressed in CD4-/CD8- immature T-cells, pre B-cells, and virgin B-cells, with expression decreasing at more mature stages of B-cell development. Overexpression of TCL1B has been implicated in the development of mature T-cell leukemia, with chromosomal rearrangements bringing the gene in close proximity to T-cell antigen receptor regulatory elements. Additionally, TCL1B has been associated with lymphatic system diseases and immune system disorders.