抗人 TCF20 抗体对
01AB01376
Transcription factor 20 (TCF20) is a nuclear protein encoded by the TCF20 gene that functions primarily as a transcriptional coactivator, binding to regulatory DNA elements such as the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (MMP3) promoter and controlling stromelysin expression. TCF20 displays DNA-binding and transactivation activities, enhancing the function of multiple transcription factors including JUN, SP1, PAX6, and others, thereby influencing a wide range of physiological processes such as DNA damage repair, epigenetic gene regulation, protein modification, signal transduction, cellular proliferation, differentiation, apoptosis, neuronal and synaptic development, immune response, and lipid metabolism. The protein contains several functional domains, including nuclear localization sequences, AT-hook, DNA-binding, PHD, and zinc-finger domains, and alternative splicing results in different isoforms. Pathogenic variants in TCF20, particularly those causing loss of key domains, are associated with neurodevelopmental disorders, as they disrupt its regulatory functions and affect the activity of related transcription factors, leading to developmental and neurological abnormalities.
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技术参数
- 靶点基因名
- TCF20
- 基因别名
- KIAA0292; SPBP
- 蛋白别名
- transcription factor 20; TCF20
- UniProt
- Q9UGU0
- 物种
- Human
产品详情
- 靶点名称
- TCF20
- 蛋白名称
- transcription factor 20
- 蛋白别名
- Transcription factor 20; TCF-20; Nuclear factor SPBP; Protein AR1; Stromelysin-1 PDGF-responsive element-binding protein; SPRE-binding protein
- 靶点基因名
- TCF20
- 基因别名
- KIAA0292; SPBP
- UniProt
- Q9UGU0
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Transcription factor 20 (TCF20) is a nuclear protein encoded by the TCF20 gene that functions primarily as a transcriptional coactivator, binding to regulatory DNA elements such as the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (MMP3) promoter and controlling stromelysin expression. TCF20 displays DNA-binding and transactivation activities, enhancing the function of multiple transcription factors including JUN, SP1, PAX6, and others, thereby influencing a wide range of physiological processes such as DNA damage repair, epigenetic gene regulation, protein modification, signal transduction, cellular proliferation, differentiation, apoptosis, neuronal and synaptic development, immune response, and lipid metabolism. The protein contains several functional domains, including nuclear localization sequences, AT-hook, DNA-binding, PHD, and zinc-finger domains, and alternative splicing results in different isoforms. Pathogenic variants in TCF20, particularly those causing loss of key domains, are associated with neurodevelopmental disorders, as they disrupt its regulatory functions and affect the activity of related transcription factors, leading to developmental and neurological abnormalities.