人 TBC1D17 抗体对
01AB02694
TBC1 domain family member 17 (TBC1D17), is a probable RAB GTPase-activating protein (GAP) that primarily inhibits RAB8A/B function, reducing Rab8 recruitment to tubules from the endocytic recycling compartment (ERC) and thereby suppressing Rab8-mediated endocytic trafficking, such as that of the transferrin receptor. Predicted to enable GTPase activator activity, it participates in retrograde transport from endosomes to Golgi, regulation of autophagy, and vesicle-mediated transport pathways, with localization in the cytosol; it spans 344 amino acids in humans and has paralogs like TBC1D15. Diseases linked to TBC1D17 include glaucoma, normal tension, and primary open angle glaucoma.
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技术参数
- 靶点基因名
- TBC1D17
- 蛋白别名
- TBC1 domain family member 17; TBC1D17
- UniProt
- Q9HA65
- 物种
- Human
产品详情
- 靶点名称
- TBC1D17
- 蛋白名称
- TBC1 domain family member 17
- 蛋白别名
- TBC1 domain family member 17
- 靶点基因名
- TBC1D17
- UniProt
- Q9HA65
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
TBC1 domain family member 17 (TBC1D17), is a probable RAB GTPase-activating protein (GAP) that primarily inhibits RAB8A/B function, reducing Rab8 recruitment to tubules from the endocytic recycling compartment (ERC) and thereby suppressing Rab8-mediated endocytic trafficking, such as that of the transferrin receptor. Predicted to enable GTPase activator activity, it participates in retrograde transport from endosomes to Golgi, regulation of autophagy, and vesicle-mediated transport pathways, with localization in the cytosol; it spans 344 amino acids in humans and has paralogs like TBC1D15. Diseases linked to TBC1D17 include glaucoma, normal tension, and primary open angle glaucoma.