人 TBC1D13 抗体对
01AB03029
TBC1 domain family member 13 (TBC1D13) is a cytosolic and membrane-associated GTPase-activating protein (GAP) involved in intracellular vesicle trafficking. Characterized by a conserved TBC (Tre-2/Bub2/Cdc16) domain, it functions as a specific regulator of the small GTPase RAB35. Through this interaction, TBC1D13 modulates Rab-dependent membrane dynamics, including the insulin-stimulated translocation of the glucose transporter GLUT4 to the plasma membrane in adipocytes, implicating it in systemic glucose homeostasis. While widely expressed and structurally defining a component of the transport machinery, TBC1D13 is not currently linked to specific monogenic disorders, though its function suggests relevance to metabolic regulation and cellular transport pathways.
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技术参数
- 靶点基因名
- TBC1D13
- 蛋白别名
- TBC1 domain family member 13; TBC1D13
- UniProt
- Q9NVG8
- 物种
- Human
产品详情
- 靶点名称
- TBC1D13
- 蛋白名称
- TBC1 domain family member 13
- 蛋白别名
- TBC1 domain family member 13
- 靶点基因名
- TBC1D13
- UniProt
- Q9NVG8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
TBC1 domain family member 13 (TBC1D13) is a cytosolic and membrane-associated GTPase-activating protein (GAP) involved in intracellular vesicle trafficking. Characterized by a conserved TBC (Tre-2/Bub2/Cdc16) domain, it functions as a specific regulator of the small GTPase RAB35. Through this interaction, TBC1D13 modulates Rab-dependent membrane dynamics, including the insulin-stimulated translocation of the glucose transporter GLUT4 to the plasma membrane in adipocytes, implicating it in systemic glucose homeostasis. While widely expressed and structurally defining a component of the transport machinery, TBC1D13 is not currently linked to specific monogenic disorders, though its function suggests relevance to metabolic regulation and cellular transport pathways.