抗人 Tau 抗体对
01AB01899
Human Tau is a protein that helps stabilize the internal skeleton of nerve cells (neurons) in the brain. This internal skeleton has a tube-like shape through which molecules are transported across the cell. Tau stabilizes the microtubules that make up this skeleton to help them function best. Tau is found mostly in the messenger cells of our brains, called neurons, and is predominantly expressed in the neurons of the cerebral cortex where it has the highest abundance. In Alzheimer's disease, an abnormal form of tau accumulates and begins sticking together in thread-like structures called neurofibrillary tangles. These tangles are not effectively disposed of through the cell’s usual ways of removing “trash.” The build-up damages the disrupting how neurons function. Tau tangles start in the brainstem, which connects the brain to the spinal cord. Elevated tau levels are observed in the brain decades before the onset of Alzheimer’s disease symptoms like memory loss.
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技术参数
- 靶点基因名
- MAPT
- 蛋白别名
- Microtubule-associated protein tau; Tau
- UniProt
- P10636-8
- 物种
- Human
产品详情
- 靶点名称
- Tau
- 蛋白名称
- Microtubule-associated protein tau
- 靶点基因名
- MAPT
- UniProt
- P10636-8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Human Tau is a protein that helps stabilize the internal skeleton of nerve cells (neurons) in the brain. This internal skeleton has a tube-like shape through which molecules are transported across the cell. Tau stabilizes the microtubules that make up this skeleton to help them function best. Tau is found mostly in the messenger cells of our brains, called neurons, and is predominantly expressed in the neurons of the cerebral cortex where it has the highest abundance. In Alzheimer's disease, an abnormal form of tau accumulates and begins sticking together in thread-like structures called neurofibrillary tangles. These tangles are not effectively disposed of through the cell’s usual ways of removing “trash.” The build-up damages the disrupting how neurons function. Tau tangles start in the brainstem, which connects the brain to the spinal cord. Elevated tau levels are observed in the brain decades before the onset of Alzheimer’s disease symptoms like memory loss.