人 Tau-441 抗体对
01AB03505
Total Tau encompasses the aggregate measurement of all soluble tau isoforms and fragments present in a biological sample, typically utilizing antibodies directed against the immunogenic mid-domain region. Physiologically, tau stabilizes microtubules to support axonal transport, but pathological conditions or acute injury lead to its release into extracellular fluids. While cerebrospinal fluid levels serve as a classic marker of neurodegeneration in Alzheimer's disease, plasma measurements are historically limited by significant interference from peripheral non-brain tau sources. Consequently, its primary clinical utility in blood often lies in detecting acute and rapid neuronal damage, such as in Creutzfeldt-Jakob disease, stroke, or traumatic brain injury, rather than serving as a specific diagnostic tool for early-stage Alzheimer's pathology.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- MAPT
- 基因别名
- MAPTL; MTBT1; TAU
- 蛋白别名
- Microtubule-associated protein tau; Tau-441
- UniProt
- P10636-8
- 物种
- Human
产品详情
- 靶点名称
- Tau-441
- 蛋白名称
- Microtubule-associated protein tau
- 靶点基因名
- MAPT
- 基因别名
- MAPTL; MTBT1; TAU
- UniProt
- P10636-8
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Total Tau encompasses the aggregate measurement of all soluble tau isoforms and fragments present in a biological sample, typically utilizing antibodies directed against the immunogenic mid-domain region. Physiologically, tau stabilizes microtubules to support axonal transport, but pathological conditions or acute injury lead to its release into extracellular fluids. While cerebrospinal fluid levels serve as a classic marker of neurodegeneration in Alzheimer's disease, plasma measurements are historically limited by significant interference from peripheral non-brain tau sources. Consequently, its primary clinical utility in blood often lies in detecting acute and rapid neuronal damage, such as in Creutzfeldt-Jakob disease, stroke, or traumatic brain injury, rather than serving as a specific diagnostic tool for early-stage Alzheimer's pathology.