抗人 TAOK1 抗体对
01AB02736
TAO kinase 1 (TAOK1) is a STE20-family serine/threonine-protein kinase that associates with the microtubule cytoskeleton and nuclear bodies. It serves as an upstream activator of the p38/MAPK14 stress-activated cascade by phosphorylating MAP2K3 and MAP2K6. TAOK1 also regulates cytoskeletal stability by activating MARK2, which promotes the detachment of tau from microtubules, and is essential for proper chromosome congression and mitotic progression. Clinically, heterozygous pathogenic variants in TAOK1 cause an autosomal dominant neurodevelopmental disorder characterized by developmental delay and intellectual impairment. Additionally, TAOK1 is implicated in the pathogenesis of Alzheimer-related tau pathology and has been linked to inflammatory IL-17 signaling and fibrogenesis, suggesting a broad role in both developmental and degenerative diseases.
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技术参数
- 靶点基因名
- TAOK1
- 基因别名
- KIAA1361; MAP3K16; MARKK
- 蛋白别名
- TAO kinase 1; TAOK1
- UniProt
- Q7L7X3
- 物种
- Human
产品详情
- 靶点名称
- TAOK1
- 蛋白名称
- TAO kinase 1
- 蛋白别名
- Serine/threonine-protein kinase TAO1; Kinase from chicken homolog B; hKFC-B; MARK Kinase; MARKK; Prostate-derived sterile 20-like kinase 2; PSK-2; PSK2; Prostate-derived STE20-like kinase 2; Thousand and one amino acid protein kinase 1; TAOK1; hTAOK1
- 靶点基因名
- TAOK1
- 基因别名
- KIAA1361; MAP3K16; MARKK
- UniProt
- Q7L7X3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
TAO kinase 1 (TAOK1) is a STE20-family serine/threonine-protein kinase that associates with the microtubule cytoskeleton and nuclear bodies. It serves as an upstream activator of the p38/MAPK14 stress-activated cascade by phosphorylating MAP2K3 and MAP2K6. TAOK1 also regulates cytoskeletal stability by activating MARK2, which promotes the detachment of tau from microtubules, and is essential for proper chromosome congression and mitotic progression. Clinically, heterozygous pathogenic variants in TAOK1 cause an autosomal dominant neurodevelopmental disorder characterized by developmental delay and intellectual impairment. Additionally, TAOK1 is implicated in the pathogenesis of Alzheimer-related tau pathology and has been linked to inflammatory IL-17 signaling and fibrogenesis, suggesting a broad role in both developmental and degenerative diseases.