抗人 TANK 抗体对
01AB01375
TANK is a crucial regulator of NF-κB signaling, playing a significant role in immune responses and inflammation. TANK acts as a negative regulator of NF-κB activation induced by DNA damage, interleukin-1β, and Toll-like receptor stimulation. It forms a complex with MCPIP1 and the deubiquitinase USP10, which facilitates the deubiquitination of TRAF6, thereby inhibiting NF-κB activation. This regulatory function of TANK is essential for maintaining the balance of inflammatory responses and preventing excessive inflammation. In terms of disease associations, TANK has been linked to enhanced aversive emotional processing, which may protect against the development of alcohol drinking behavior. Additionally, the TANK-mediated regulation of NF-κB signaling is crucial in various immune-related processes, including T-cell activation and differentiation, which are implicated in autoimmune diseases and inflammatory disorders.
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技术参数
- 靶点基因名
- TANK
- 基因别名
- ITRAF; TRAF2
- 蛋白别名
- TRAF family member associated NFKB activator; TANK
- UniProt
- Q92844
- 物种
- Human
产品详情
- 靶点名称
- TANK
- 蛋白名称
- TRAF family member associated NFKB activator
- 蛋白别名
- TRAF family member-associated NF-kappa-B activator; TRAF-interacting protein; I-TRAF
- 靶点基因名
- TANK
- 基因别名
- ITRAF; TRAF2
- UniProt
- Q92844
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
TANK is a crucial regulator of NF-κB signaling, playing a significant role in immune responses and inflammation. TANK acts as a negative regulator of NF-κB activation induced by DNA damage, interleukin-1β, and Toll-like receptor stimulation. It forms a complex with MCPIP1 and the deubiquitinase USP10, which facilitates the deubiquitination of TRAF6, thereby inhibiting NF-κB activation. This regulatory function of TANK is essential for maintaining the balance of inflammatory responses and preventing excessive inflammation. In terms of disease associations, TANK has been linked to enhanced aversive emotional processing, which may protect against the development of alcohol drinking behavior. Additionally, the TANK-mediated regulation of NF-κB signaling is crucial in various immune-related processes, including T-cell activation and differentiation, which are implicated in autoimmune diseases and inflammatory disorders.