抗人 TALDO1 抗体对
01AB01373
Transaldolase 1 (TALDO1) is a cytosolic enzyme crucial for the non-oxidative phase of the pentose phosphate pathway, where it catalyzes the reversible transfer of a three-carbon dihydroxyacetone unit from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing erythrose-4-phosphate and fructose-6-phosphate. Structurally, human transaldolase consists of 337 amino acids forming a single α/β barrel domain, with the active site containing lysine-142, glutamate-106, and aspartate-27, which are essential for its catalytic mechanism involving Schiff base formation and proton transfer. The enzyme functions as a dimer and is vital for generating ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. Deficiency or mutations in TALDO1 can disrupt the pentose phosphate pathway, leading to transaldolase deficiency, a rare metabolic disorder characterized by liver dysfunction, coagulopathy, and multi-organ involvement due to impaired redox balance and nucleotide synthesis.
| 规格 | 起售价 |
|---|---|
| 登录后可查看 | |
技术参数
- 靶点基因名
- TALDO1
- 基因别名
- TAL; TALDO; TALDOR
- 蛋白别名
- transaldolase 1; TALDO1
- UniProt
- P37837
- 物种
- Human
产品详情
- 靶点名称
- TALDO1
- 蛋白名称
- transaldolase 1
- 蛋白别名
- Transaldolase
- 靶点基因名
- TALDO1
- 基因别名
- TAL; TALDO; TALDOR
- UniProt
- P37837
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Transaldolase 1 (TALDO1) is a cytosolic enzyme crucial for the non-oxidative phase of the pentose phosphate pathway, where it catalyzes the reversible transfer of a three-carbon dihydroxyacetone unit from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing erythrose-4-phosphate and fructose-6-phosphate. Structurally, human transaldolase consists of 337 amino acids forming a single α/β barrel domain, with the active site containing lysine-142, glutamate-106, and aspartate-27, which are essential for its catalytic mechanism involving Schiff base formation and proton transfer. The enzyme functions as a dimer and is vital for generating ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. Deficiency or mutations in TALDO1 can disrupt the pentose phosphate pathway, leading to transaldolase deficiency, a rare metabolic disorder characterized by liver dysfunction, coagulopathy, and multi-organ involvement due to impaired redox balance and nucleotide synthesis.