人 TAFA1 抗体对
01AB00602
TAFA chemokine like family member 1 (TAFA1), also known as FAM19A1, is a secreted protein belonging to the TAFA family, which shares structural homology with chemokines but lacks typical chemokine receptor-binding motifs. TAFA1 is a 43 kDa protein encoded by the FAM19A1 gene, containing conserved cysteine residues forming a disulfide-bonded structure. It is predominantly expressed in the brain, particularly in neurons, and plays roles in immune modulation, neurodevelopment, and synaptic plasticity. TAFA1 interacts with G-protein-coupled receptors (GPCRs) to regulate cell migration and inflammatory responses. Disease associations include links to neuroinflammatory and neurodegenerative conditions, such as Alzheimer’s disease, where altered TAFA1 expression may influence microglial activation and amyloid-beta clearance.
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技术参数
- 靶点基因名
- TAFA1
- 基因别名
- FAM19A1
- 蛋白别名
- TAFA chemokine like family member 1; TAFA1
- UniProt
- Q7Z5A9
- 物种
- Human
产品详情
- 靶点名称
- TAFA1
- 蛋白名称
- TAFA chemokine like family member 1
- 蛋白别名
- Chemokine-like protein TAFA-1
- 靶点基因名
- TAFA1
- 基因别名
- FAM19A1
- UniProt
- Q7Z5A9
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
TAFA chemokine like family member 1 (TAFA1), also known as FAM19A1, is a secreted protein belonging to the TAFA family, which shares structural homology with chemokines but lacks typical chemokine receptor-binding motifs. TAFA1 is a 43 kDa protein encoded by the FAM19A1 gene, containing conserved cysteine residues forming a disulfide-bonded structure. It is predominantly expressed in the brain, particularly in neurons, and plays roles in immune modulation, neurodevelopment, and synaptic plasticity. TAFA1 interacts with G-protein-coupled receptors (GPCRs) to regulate cell migration and inflammatory responses. Disease associations include links to neuroinflammatory and neurodegenerative conditions, such as Alzheimer’s disease, where altered TAFA1 expression may influence microglial activation and amyloid-beta clearance.