抗人 TAF5L 抗体对
01AB01369
TATA-box binding protein associated factor 5 like (TAF5L) is a WD-repeat protein that functions as a key component of the PCAF (p300/CBP-associated factor) histone acetylase complex, which acetylates histones in a nucleosomal context to regulate chromatin structure and gene transcription. Structurally similar to the histone-like TAF5, TAF5L facilitates transcription initiation by promoting the recruitment of transcription factors such as TFIID and modifying general transcription factors to enable assembly of the transcriptional machinery. It acts as a transcriptional coactivator and is essential for myogenic differentiation and embryonic stem cell gene expression programs through epigenetic regulation. Disease associations include Heinz Body Anemia, suggesting a role in hematological conditions.
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技术参数
- 靶点基因名
- TAF5L
- 基因别名
- PAF65B
- 蛋白别名
- TATA-box binding protein associated factor 5 like; TAF5L
- UniProt
- O75529
- 物种
- Human
产品详情
- 靶点名称
- TAF5L
- 蛋白名称
- TATA-box binding protein associated factor 5 like
- 蛋白别名
- TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; TAF5L; PCAF-associated factor 65 beta; PAF65-beta
- 靶点基因名
- TAF5L
- 基因别名
- PAF65B
- UniProt
- O75529
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
TATA-box binding protein associated factor 5 like (TAF5L) is a WD-repeat protein that functions as a key component of the PCAF (p300/CBP-associated factor) histone acetylase complex, which acetylates histones in a nucleosomal context to regulate chromatin structure and gene transcription. Structurally similar to the histone-like TAF5, TAF5L facilitates transcription initiation by promoting the recruitment of transcription factors such as TFIID and modifying general transcription factors to enable assembly of the transcriptional machinery. It acts as a transcriptional coactivator and is essential for myogenic differentiation and embryonic stem cell gene expression programs through epigenetic regulation. Disease associations include Heinz Body Anemia, suggesting a role in hematological conditions.