抗人 TACSTD2 抗体对
01AB00965
Tumor associated calcium signal transducer 2 (TACSTD2), also known as TROP-2, is a type I transmembrane glycoprotein encoded by an intronless gene located on chromosome 1p32.1. It functions as a cell surface receptor that transduces calcium signals and is involved in cell-cell adhesion. TACSTD2 is expressed in various epithelial tissues and plays a role in regulating cell proliferation, migration, and invasion. The protein has a molecular weight of 35-50 kDa and contains extracellular, transmembrane, and cytoplasmic domains. TACSTD2 is overexpressed in multiple types of epithelial cancers, including colorectal, breast, and lung cancers, where it is associated with tumor progression and poor prognosis. In non-cancerous conditions, mutations in TACSTD2 can cause gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis.
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技术参数
- 靶点基因名
- TACSTD2
- 基因别名
- GA733-1; M1S1; TROP2
- 蛋白别名
- tumor associated calcium signal transducer 2; TACSTD2
- UniProt
- P09758
- 物种
- Human
产品详情
- 靶点名称
- TACSTD2
- 蛋白名称
- tumor associated calcium signal transducer 2
- 蛋白别名
- Tumor-associated calcium signal transducer 2; Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1
- 靶点基因名
- TACSTD2
- 基因别名
- GA733-1; M1S1; TROP2
- UniProt
- P09758
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Tumor associated calcium signal transducer 2 (TACSTD2), also known as TROP-2, is a type I transmembrane glycoprotein encoded by an intronless gene located on chromosome 1p32.1. It functions as a cell surface receptor that transduces calcium signals and is involved in cell-cell adhesion. TACSTD2 is expressed in various epithelial tissues and plays a role in regulating cell proliferation, migration, and invasion. The protein has a molecular weight of 35-50 kDa and contains extracellular, transmembrane, and cytoplasmic domains. TACSTD2 is overexpressed in multiple types of epithelial cancers, including colorectal, breast, and lung cancers, where it is associated with tumor progression and poor prognosis. In non-cancerous conditions, mutations in TACSTD2 can cause gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis.