人 TACC2 抗体对
01AB03176
Transforming acidic coiled-coil-containing protein 2 (TACC2) is a centrosomal protein essential for mitotic spindle organization. It facilitates the coupling of the centrosome to the nucleus and stabilizes microtubules during cell division. TACC2 expression is hormonally responsive, notably to erythropoietin and androgens. In cancer, TACC2 plays a context-dependent role; it is associated with breast and prostate malignancies where it can function as a tumor suppressor or progression marker. Its dysregulation affects cell cycle fidelity and has been linked to specific subtypes like mucinous stomach adenocarcinoma.
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技术参数
- 靶点基因名
- TACC2
- 蛋白别名
- transforming acidic coiled-coil containing protein 2; TACC2
- UniProt
- O95359
- 物种
- Human
产品详情
- 靶点名称
- TACC2
- 蛋白名称
- transforming acidic coiled-coil containing protein 2
- 蛋白别名
- Transforming acidic coiled-coil-containing protein 2; Anti-Zuai-1; AZU-1
- 靶点基因名
- TACC2
- UniProt
- O95359
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Transforming acidic coiled-coil-containing protein 2 (TACC2) is a centrosomal protein essential for mitotic spindle organization. It facilitates the coupling of the centrosome to the nucleus and stabilizes microtubules during cell division. TACC2 expression is hormonally responsive, notably to erythropoietin and androgens. In cancer, TACC2 plays a context-dependent role; it is associated with breast and prostate malignancies where it can function as a tumor suppressor or progression marker. Its dysregulation affects cell cycle fidelity and has been linked to specific subtypes like mucinous stomach adenocarcinoma.