人 T Cell Leukemia/Lymphoma Protein 1A 抗体对
01AB02319
TCL1 family AKT coactivator A (TCL1A) is a 13 kDa protein encoded on human chromosome 14 that functions as a critical coactivator of AKT kinases (AKT1, AKT2, and AKT3), enhancing their phosphorylation, activation, and nuclear translocation to promote cell proliferation and survival. Under normal physiological conditions, TCL1A is expressed in fetal tissues and early developmental stage lymphocytes, particularly in CD4-/CD8- thymocytes, where it mediates appropriate growth signals. However, dysregulation of TCL1A expression through chromosomal translocations that position the gene near T-cell receptor regulatory elements leads to oncogenic transformation. TCL1A overexpression is implicated in multiple hematologic malignancies, including chronic lymphocytic leukemia (B-CLL), T-cell prolymphocytic leukemia (T-PLL), and precursor T-cell acute lymphoblastic leukemia. Beyond AKT signaling, TCL1A regulates the PI3K/AKT/mTOR pathway, NF-κB signaling through interaction with ATM and IκB, and modulates tumor suppressors like PTPROt, collectively driving lymphomagenesis and genome instability in affected cells.
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技术参数
- 靶点基因名
- TCL1A
- 基因别名
- TCL1
- 蛋白别名
- TCL1 family AKT coactivator A; T Cell Leukemia/Lymphoma Protein 1A
- UniProt
- P56279
- 物种
- Human
产品详情
- 靶点名称
- T Cell Leukemia/Lymphoma Protein 1A
- 蛋白名称
- TCL1 family AKT coactivator A
- 蛋白别名
- T-cell leukemia/lymphoma protein 1A; Oncogene TCL-1; Oncogene TCL1; Protein p14 TCL1
- 靶点基因名
- TCL1A
- 基因别名
- TCL1
- UniProt
- P56279
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
TCL1 family AKT coactivator A (TCL1A) is a 13 kDa protein encoded on human chromosome 14 that functions as a critical coactivator of AKT kinases (AKT1, AKT2, and AKT3), enhancing their phosphorylation, activation, and nuclear translocation to promote cell proliferation and survival. Under normal physiological conditions, TCL1A is expressed in fetal tissues and early developmental stage lymphocytes, particularly in CD4-/CD8- thymocytes, where it mediates appropriate growth signals. However, dysregulation of TCL1A expression through chromosomal translocations that position the gene near T-cell receptor regulatory elements leads to oncogenic transformation. TCL1A overexpression is implicated in multiple hematologic malignancies, including chronic lymphocytic leukemia (B-CLL), T-cell prolymphocytic leukemia (T-PLL), and precursor T-cell acute lymphoblastic leukemia. Beyond AKT signaling, TCL1A regulates the PI3K/AKT/mTOR pathway, NF-κB signaling through interaction with ATM and IκB, and modulates tumor suppressors like PTPROt, collectively driving lymphomagenesis and genome instability in affected cells.