人 SWAP70 抗体对
01AB02549
Switching B cell complex subunit SWAP70 (SWAP70) is a 69 kDa scaffolding protein that functions as a phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor. It is predominantly expressed in B cells and mast cells, where it regulates actin cytoskeleton dynamics through its PH and F-actin binding domains. SWAP70 coordinates the organization of F-actin filaments to promote membrane ruffling, phagosome formation, and B cell homing. Upon activation of the B cell receptor or CD40, the protein translocates from the cytoplasm to the plasma membrane and nucleus to facilitate signaling. Clinically, SWAP70 is essential for proper immune function, as its deficiency impairs plasma cell generation and overall immune responses. Additionally, it is involved in the pathogenesis of Kaposi's sarcoma, where it is required for the aberrant activation of RAC1 that drives tumor cell motility and growth.
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技术参数
- 靶点基因名
- SWAP70
- 基因别名
- KIAA0640
- 蛋白别名
- switching B cell complex subunit SWAP70; SWAP70
- UniProt
- Q9UH65
- 物种
- Human
产品详情
- 靶点名称
- SWAP70
- 蛋白名称
- switching B cell complex subunit SWAP70
- 蛋白别名
- Switch-associated protein 70; SWAP-70
- 靶点基因名
- SWAP70
- 基因别名
- KIAA0640
- UniProt
- Q9UH65
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Switching B cell complex subunit SWAP70 (SWAP70) is a 69 kDa scaffolding protein that functions as a phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor. It is predominantly expressed in B cells and mast cells, where it regulates actin cytoskeleton dynamics through its PH and F-actin binding domains. SWAP70 coordinates the organization of F-actin filaments to promote membrane ruffling, phagosome formation, and B cell homing. Upon activation of the B cell receptor or CD40, the protein translocates from the cytoplasm to the plasma membrane and nucleus to facilitate signaling. Clinically, SWAP70 is essential for proper immune function, as its deficiency impairs plasma cell generation and overall immune responses. Additionally, it is involved in the pathogenesis of Kaposi's sarcoma, where it is required for the aberrant activation of RAC1 that drives tumor cell motility and growth.