人 SV2A 抗体对
01AB00113
Synaptic vesicle glycoprotein 2A (SV2A) is a membrane protein present in synaptic vesicles that plays a crucial role in regulating neurotransmitter release and synaptic function. Its expression is reduced in temporal lobe epilepsy patients, and this reduction correlates with the degree of hippocampal sclerosis, suggesting a link between SV2A levels and epilepsy pathogenesis. In Alzheimer's disease (AD), SV2A mRNA and protein levels are significantly decreased in the hippocampus of AD patients compared to controls, and this reduction is consistent with the location of amyloid-beta (Aβ) deposition, implying that SV2A may interact with key AD pathogenic proteins like Aβ. Abrogation of SV2A promotes Aβ production, further supporting its involvement in AD pathogenesis.
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技术参数
- 靶点基因名
- SV2A
- 基因别名
- KIAA0736
- 蛋白别名
- synaptic vesicle glycoprotein 2A; SV2A
- UniProt
- Q7L0J3
- 物种
- Human
产品详情
- 靶点名称
- SV2A
- 蛋白名称
- synaptic vesicle glycoprotein 2A
- 蛋白别名
- Synaptic vesicle glycoprotein 2A
- 靶点基因名
- SV2A
- 基因别名
- KIAA0736
- UniProt
- Q7L0J3
- 来源物种
- Homo sapiens (Human)
- 物种反应性
- Human
背景介绍
Synaptic vesicle glycoprotein 2A (SV2A) is a membrane protein present in synaptic vesicles that plays a crucial role in regulating neurotransmitter release and synaptic function. Its expression is reduced in temporal lobe epilepsy patients, and this reduction correlates with the degree of hippocampal sclerosis, suggesting a link between SV2A levels and epilepsy pathogenesis. In Alzheimer's disease (AD), SV2A mRNA and protein levels are significantly decreased in the hippocampus of AD patients compared to controls, and this reduction is consistent with the location of amyloid-beta (Aβ) deposition, implying that SV2A may interact with key AD pathogenic proteins like Aβ. Abrogation of SV2A promotes Aβ production, further supporting its involvement in AD pathogenesis.